Phytochemical Screening, Phenolic Content, and Anti-Inflammatory Effect of Foeniculum vulgare Seed Extract.

IF 1.6 Q3 FOOD SCIENCE & TECHNOLOGY
Asma Cherbal, Mouna Bouabdallah, Mouna Benhalla, Saliha Hireche, Rachid Desdous
{"title":"Phytochemical Screening, Phenolic Content, and Anti-Inflammatory Effect of <i>Foeniculum vulgare</i> Seed Extract.","authors":"Asma Cherbal,&nbsp;Mouna Bouabdallah,&nbsp;Mouna Benhalla,&nbsp;Saliha Hireche,&nbsp;Rachid Desdous","doi":"10.3746/pnf.2023.28.2.141","DOIUrl":null,"url":null,"abstract":"<p><p>Medicinal plants are promising sources of natural substances with biological functions and several drugs have been developed from traditional medicine. This study aimed to determine the chemical components of a hydromethanolic extract from <i>Foeniculum vulgare</i> seeds. Total phenolic, flavonoid, and flavonol contents were assessed, and gas chromatography-mass spectrometry (GC-MS) analysis was performed. To investigate the anti-inflammatory activity of <i>F. vulgare</i> seed hydromethanolic extract, its effects on protein denaturation, protease activity, membrane stabilization, and heat-induced hemolysis in red blood cells were evaluated <i>in vitro</i>. <i>F. vulgare</i> seed extract showed significant inhibition of protein denaturation (35.68±0.4%), protease activity (58.09±0.1%), and heat-induced hemolysis in red blood cells (9.67±0.3%) at concentrations of 200, 250, and 200 μg/mL, respectively, compared to the reference drug indomethacin (<i>P</i><0.001). This remarkable anti-inflammatory activity may be attributable to the abundance of flavonoids in the <i>F. vulgare</i> seed extract. GC-MS confirmed the presence of linalool and fatty acids (palmitic and oleic acids), which have potential anti-inflammatory activities. Therefore, the hydromethanolic extract of <i>F. vulgare</i> seeds may be a valuable anti-inflammatory candidate in the years ahead.</p>","PeriodicalId":20424,"journal":{"name":"Preventive Nutrition and Food Science","volume":"28 2","pages":"141-148"},"PeriodicalIF":1.6000,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/68/44/pnfs-28-2-141.PMC10321444.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Preventive Nutrition and Food Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3746/pnf.2023.28.2.141","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
引用次数: 1

Abstract

Medicinal plants are promising sources of natural substances with biological functions and several drugs have been developed from traditional medicine. This study aimed to determine the chemical components of a hydromethanolic extract from Foeniculum vulgare seeds. Total phenolic, flavonoid, and flavonol contents were assessed, and gas chromatography-mass spectrometry (GC-MS) analysis was performed. To investigate the anti-inflammatory activity of F. vulgare seed hydromethanolic extract, its effects on protein denaturation, protease activity, membrane stabilization, and heat-induced hemolysis in red blood cells were evaluated in vitro. F. vulgare seed extract showed significant inhibition of protein denaturation (35.68±0.4%), protease activity (58.09±0.1%), and heat-induced hemolysis in red blood cells (9.67±0.3%) at concentrations of 200, 250, and 200 μg/mL, respectively, compared to the reference drug indomethacin (P<0.001). This remarkable anti-inflammatory activity may be attributable to the abundance of flavonoids in the F. vulgare seed extract. GC-MS confirmed the presence of linalool and fatty acids (palmitic and oleic acids), which have potential anti-inflammatory activities. Therefore, the hydromethanolic extract of F. vulgare seeds may be a valuable anti-inflammatory candidate in the years ahead.

Abstract Image

Abstract Image

Abstract Image

小茴香种子提取物的植物化学筛选、酚类含量及抗炎作用。
药用植物是具有生物功能的天然物质的重要来源,从传统医药中开发出多种药物。本研究旨在测定小茴香种子的氢甲醇提取物的化学成分。测定总酚、类黄酮和黄酮醇含量,并进行气相色谱-质谱(GC-MS)分析。为了研究淫羊藿种子氢甲醇提取物的抗炎作用,采用体外实验研究其对红细胞蛋白变性、蛋白酶活性、膜稳定性和热溶血的影响。与对照药吲哚美辛(PF. vulgare seed提取物)相比,200、250和200 μg/mL浓度下,其对红细胞蛋白变性(35.68±0.4%)、蛋白酶活性(58.09±0.1%)和热溶血(9.67±0.3%)的抑制作用显著。GC-MS证实了芳樟醇和脂肪酸(棕榈酸和油酸)的存在,它们具有潜在的抗炎活性。因此,淫羊藿种子的氢甲醇提取物可能是未来几年有价值的抗炎候选物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Preventive Nutrition and Food Science
Preventive Nutrition and Food Science Agricultural and Biological Sciences-Food Science
CiteScore
3.40
自引率
0.00%
发文量
35
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信