From fetus to neonate: A review of cardiovascular modeling in early life.

IF 4.6 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Robyn W May, Gonzalo D Maso Talou, Alys R Clark, Jonathan P Mynard, Joseph J Smolich, Pablo J Blanco, Lucas O Müller, Thomas L Gentles, Frank H Bloomfield, Soroush Safaei
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引用次数: 0

Abstract

Computational modeling has well-established utility in the study of cardiovascular hemodynamics, with applications in medical research and, increasingly, in clinical settings to improve the diagnosis and treatment of cardiovascular diseases. Most cardiovascular models developed to date have been of the adult circulatory system; however, the perinatal period is unique as cardiovascular physiology undergoes drastic changes from the fetal circulation, during the birth transition, and into neonatal life. There may also be further complications in this period: for example, preterm birth (defined as birth before 37 completed weeks of gestation) carries risks of short-term cardiovascular instability and is associated with increased lifetime cardiovascular risk. Here, we review computational models of the cardiovascular system in early life, their applications to date and potential improvements and enhancements of these models. We propose a roadmap for developing an open-source cardiovascular model that spans the fetal, perinatal, and postnatal periods. This article is categorized under: Cardiovascular Diseases > Computational Models Cardiovascular Diseases > Biomedical Engineering Congenital Diseases > Computational Models.

从胎儿到新生儿:早期生命心血管模型研究综述。
计算建模在心血管血流动力学的研究中已经建立了良好的效用,在医学研究中应用,并越来越多地在临床环境中应用,以改善心血管疾病的诊断和治疗。迄今为止开发的大多数心血管模型都是针对成人循环系统的;然而,围产期是独特的,因为心血管生理经历了剧烈的变化,从胎儿循环,在出生过渡,并进入新生儿生活。在此期间还可能出现进一步的并发症:例如,早产(定义为妊娠37周前出生)具有短期心血管不稳定的风险,并与终生心血管风险增加有关。在这里,我们回顾了生命早期心血管系统的计算模型,它们迄今为止的应用以及这些模型的潜在改进和增强。我们提出了一个路线图,开发一个开源的心血管模型,跨越胎儿,围产期和产后时期。本文分类如下:心血管疾病>计算模型心血管疾病>生物医学工程先天性疾病>计算模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
WIREs Mechanisms of Disease
WIREs Mechanisms of Disease MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
11.40
自引率
0.00%
发文量
45
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