How circulating tumor cluster biology contributes to the metastatic cascade: from invasion to dissemination and dormancy.

IF 7.7 2区医学 Q1 ONCOLOGY

Cancer and Metastasis Reviews Pub Date : 2023-12-01 Epub Date: 2023-07-13 DOI:10.1007/s10555-023-10124-z

Mostafa M Nasr, Conor C Lynch

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引用次数: 0

Abstract

Circulating tumor cells (CTCs) are known to be prognostic for metastatic relapse and are detected in patients as solitary cells or cell clusters. Circulating tumor cell clusters (CTC clusters) have been observed clinically for decades and are of significantly higher metastatic potential compared to solitary CTCs. Recent studies suggest distinct differences in CTC cluster biology regarding invasion and survival in circulation. However, differences regarding dissemination, dormancy, and reawakening require more investigations compared to solitary CTCs. Here, we review the current state of CTC cluster research and consider their clinical significance. In addition, we discuss the concept of collective invasion by CTC clusters and molecular evidence as to how cluster survival in circulation compares to that of solitary CTCs. Molecular differences between solitary and clustered CTCs during dormancy and reawakening programs will also be discussed. We also highlight future directions to advance our current understanding of CTC cluster biology.

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循环肿瘤集群生物学如何促成转移级联：从入侵到扩散和休眠。

众所周知，循环肿瘤细胞（CTCs）是转移性复发的预后指标，在患者体内以单个细胞或细胞簇的形式被检测到。几十年来，临床上一直在观察循环肿瘤细胞簇（CTC 簇），与单个 CTC 相比，它们的转移潜力要高得多。最近的研究表明，循环肿瘤细胞簇在侵袭和存活方面存在明显的生物学差异。然而，与单个 CTC 相比，CTC 在扩散、休眠和苏醒方面的差异还需要更多的研究。在此，我们回顾了 CTC 簇的研究现状，并探讨了它们的临床意义。此外，我们还讨论了 CTC 簇集体入侵的概念，以及与单个 CTC 相比，CTC 簇在循环中存活的分子证据。我们还将讨论单个和集群 CTC 在休眠和苏醒过程中的分子差异。我们还将强调未来的研究方向，以推进我们目前对 CTC 簇生物学的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer and Metastasis Reviews 医学-肿瘤学

CiteScore

17.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Contemporary biomedical research is on the threshold of an era in which physiological and pathological processes can be analyzed in increasingly precise and mechanistic terms.The transformation of biology from a largely descriptive, phenomenological discipline to one in which the regulatory principles can be understood and manipulated with predictability brings a new dimension to the study of cancer and the search for effective therapeutic modalities for this disease. Cancer and Metastasis Reviews provides a forum for critical review and discussion of these challenging developments. A major function of the journal is to review some of the more important and interesting recent developments in the biology and treatment of malignant disease, as well as to highlight new and promising directions, be they technological or conceptual. Contributors are encouraged to review their personal work and be speculative.