Intracellular and microenvironmental regulation of mitochondrial membrane potential in cancer cells.

IF 4.6 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
WIREs Mechanisms of Disease Pub Date : 2023-05-01 Epub Date: 2023-01-03 DOI:10.1002/wsbm.1595
Hydari Masuma Begum, Keyue Shen
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引用次数: 0

Abstract

Cancer cells have an abnormally high mitochondrial membrane potential (ΔΨm ), which is associated with enhanced invasive properties in vitro and increased metastases in vivo. The mechanisms underlying the abnormal ΔΨm in cancer cells remain unclear. Research on different cell types has shown that ΔΨm is regulated by various intracellular mechanisms such as by mitochondrial inner and outer membrane ion transporters, cytoskeletal elements, and biochemical signaling pathways. On the other hand, the role of extrinsic, tumor microenvironment (TME) derived cues in regulating ΔΨm is not well defined. In this review, we first summarize the existing literature on intercellular mechanisms of ΔΨm regulation, with a focus on cancer cells. We then offer our perspective on the different ways through which the microenvironmental cues such as hypoxia and mechanical stresses may regulate cancer cell ΔΨm . This article is categorized under: Cancer > Environmental Factors Cancer > Biomedical Engineering Cancer > Molecular and Cellular Physiology.

Abstract Image

Abstract Image

癌细胞线粒体膜电位的胞内和微环境调控。
癌细胞的线粒体膜电位(ΔΨm)异常高,这与体外侵袭性增强和体内转移增加有关。癌细胞ΔΨm异常的机制尚不清楚。对不同类型细胞的研究表明,ΔΨm 受线粒体内外膜离子转运体、细胞骨架元素和生化信号通路等多种细胞内机制调控。另一方面,外在的、肿瘤微环境(TME)衍生线索在调节ΔΨm中的作用尚未明确。在这篇综述中,我们首先总结了有关ΔΨm调节的细胞间机制的现有文献,重点是癌细胞。然后,我们就缺氧和机械应力等微环境线索可能调控癌细胞ΔΨm的不同方式提出了自己的观点。本文归类于癌症 > 环境因素 癌症 > 生物医学工程 癌症 > 分子和细胞生理学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
WIREs Mechanisms of Disease
WIREs Mechanisms of Disease MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
11.40
自引率
0.00%
发文量
45
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