Report of Haemophilus Influenzae serotype a intracranial infections in older children.

IF 1.9 4区医学 Q2 PEDIATRICS

Pediatric Investigation Pub Date : 2023-03-18 eCollection Date: 2023-06-01 DOI:10.1002/ped4.12369

Varvara Probst, Fadi Shahoud, Aaron Fletcher Osborne, Ana Alvarez, Nizar Maraqa, Ayesha Mirza

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Abstract

Introduction: Haemophilus influenzae (Hi) is subdivided into typeable (a-f) and non-typeable groups. Hi serotype b (Hib) has historically been one of the important pathogens responsible for invasive infection. However, after widespread Hib vaccination, the emergence of other Hi serotypes, specifically Hi serotype a (Hia), was noted during the last few decades, mostly in children younger than 5 years of age.

Case presentation: We present two cases of severe intracranial infections with detected Hia in patients > 5 years of age within a short time frame and within the same geographic area.

Conclusion: Epidemiological studies and surveillance on Hia-related illnesses in all age groups worldwide are needed to better understand the clinical and epidemiological characteristics of Hia. This can establish a platform to develop a candidate vaccine against Hia that might protect children of all ages.

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大龄儿童颅内感染流感嗜血杆菌血清型 a 的报告。

导言：流感嗜血杆菌（Hi）又分为可分型（a-f）和不可分型两类。血清型 b 型流感嗜血杆菌（Hib）一直是造成入侵性感染的重要病原体之一。然而，在广泛接种 Hib 疫苗后，过去几十年中出现了其他 Hi 血清型，特别是 Hi 血清型 a（Hia），主要发生在 5 岁以下儿童中：病例介绍：我们介绍了两例颅内严重感染病例，患者年龄均大于 5 岁，且在短时间内和同一地理区域内检测到 Hia：为了更好地了解 Hia 的临床和流行病学特征，有必要对全球所有年龄组的 Hia 相关疾病进行流行病学研究和监测。结论：需要对全球所有年龄组的 Hia 相关疾病进行流行病学研究和监测，以更好地了解 Hia 的临床和流行病学特征，从而为开发可保护所有年龄组儿童的 Hia 候选疫苗建立一个平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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