Report of Haemophilus Influenzae serotype a intracranial infections in older children.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-03-18 eCollection Date: 2023-06-01 DOI:10.1002/ped4.12369

Varvara Probst, Fadi Shahoud, Aaron Fletcher Osborne, Ana Alvarez, Nizar Maraqa, Ayesha Mirza

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引用次数: 0

Abstract

Introduction: Haemophilus influenzae (Hi) is subdivided into typeable (a-f) and non-typeable groups. Hi serotype b (Hib) has historically been one of the important pathogens responsible for invasive infection. However, after widespread Hib vaccination, the emergence of other Hi serotypes, specifically Hi serotype a (Hia), was noted during the last few decades, mostly in children younger than 5 years of age.

Case presentation: We present two cases of severe intracranial infections with detected Hia in patients > 5 years of age within a short time frame and within the same geographic area.

Conclusion: Epidemiological studies and surveillance on Hia-related illnesses in all age groups worldwide are needed to better understand the clinical and epidemiological characteristics of Hia. This can establish a platform to develop a candidate vaccine against Hia that might protect children of all ages.

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大龄儿童颅内感染流感嗜血杆菌血清型 a 的报告。

导言：流感嗜血杆菌（Hi）又分为可分型（a-f）和不可分型两类。血清型 b 型流感嗜血杆菌（Hib）一直是造成入侵性感染的重要病原体之一。然而，在广泛接种 Hib 疫苗后，过去几十年中出现了其他 Hi 血清型，特别是 Hi 血清型 a（Hia），主要发生在 5 岁以下儿童中：病例介绍：我们介绍了两例颅内严重感染病例，患者年龄均大于 5 岁，且在短时间内和同一地理区域内检测到 Hia：为了更好地了解 Hia 的临床和流行病学特征，有必要对全球所有年龄组的 Hia 相关疾病进行流行病学研究和监测。结论：需要对全球所有年龄组的 Hia 相关疾病进行流行病学研究和监测，以更好地了解 Hia 的临床和流行病学特征，从而为开发可保护所有年龄组儿童的 Hia 候选疫苗建立一个平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.