Saponin protects against cyclophosphamide-induced kidney and liver damage via antioxidant and anti-inflammatory actions.

IF 2.2 4区医学 Q3 PHYSIOLOGY

Physiology international Pub Date : 2023-06-12 DOI:10.1556/2060.2023.00190

Mohammad Ghasem Golmohammadi, Shokofeh Banaei, Mojgan Timar, Ali Abedi

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引用次数: 2

Abstract

Background: The liver and kidney are organs affected by chemotherapy drugs such as cyclophosphamide (CP). This study examined the protective effects of treatment with saponin (SP) against CP-induced nephrotoxicity and hepatotoxicity.

Methods: 24 adult male mice were divided into four groups (N = 6): Control group, CP (15 mg kg-1), SP (2.5 mg kg-1) and CP + SP. After treatment, blood samples were collected for the determination of biochemical parameters. Liver and kidney samples were taken for histological analysis and assessment of oxidative stress and inflammatory markers.

Results: Cyclophosphamide decreased renal and liver functions and antioxidant enzymes, which significantly increased blood urea nitrogen and creatinine (BUN, Cr), liver enzyme levels, malondialdehyde, nuclear factor kappa β (NF-kB) and Interleukin 1 beta (IL-1B) concentrations. Moreover, histopathological findings of the CP group showed that there were acute tubular necrosis and glomerular atrophy in the renal tissues and lymphocyte infiltration in the liver samples. Treatment with saponin improved hepatic and renal functions, pathological changes and antioxidant capacity, and also decreased lipid peroxidation and inflammation.

Conclusion: It seems that saponin could exert a hepato-nephroprotective effect against cyclophosphamide toxicity.

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皂苷通过抗氧化和抗炎作用防止环磷酰胺引起的肾和肝损伤。

背景:肝和肾是化疗药物如环磷酰胺(CP)影响的器官。本研究探讨了皂苷(SP)对cp诱导的肾毒性和肝毒性的保护作用。方法:将24只成年雄性小鼠分为4组(N = 6):对照组、CP组(15 mg kg-1)、SP组(2.5 mg kg-1)和CP + SP组，处理后采血测定生化指标。取肝脏和肾脏标本进行组织学分析，评估氧化应激和炎症标志物。结果:环磷酰胺降低肾功能、肝功能及抗氧化酶，显著升高血尿素氮、肌酐(BUN、Cr)、肝酶水平、丙二醛、核因子κ β (NF-kB)、白细胞介素1 β (IL-1B)浓度。CP组肾组织病理表现为急性肾小管坏死、肾小球萎缩，肝脏淋巴细胞浸润。皂苷可改善肝肾功能、病理改变和抗氧化能力，降低脂质过氧化和炎症反应。结论:皂苷具有抗环磷酰胺毒性的肝肾保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physiology international Medicine-Physiology (medical)

CiteScore

3.40

自引率

0.00%

发文量

期刊介绍： The journal provides a forum for important new research papers written by eminent scientists on experimental medical sciences. Papers reporting on both original work and review articles in the fields of basic and clinical physiology, pathophysiology (from the subcellular organization level up to the oranizmic one), as well as related disciplines, including history of physiological sciences, are accepted.