"En Face" Spectral-Domain Optical Coherence Tomography versus Multifocal Electroretinogram in Hydroxychloroquine Retinopathy Screening.

IF 2.1 4区医学 Q2 OPHTHALMOLOGY

Ophthalmologica Pub Date : 2023-01-01 DOI:10.1159/000528146

Martine Mauget-Faÿsse, Georges Sukkarieh, Hajar Jebrane, Justine Lafolie, Anne Sophie Alonso, Elsa Laumonier, Sabine Derrien, Veronique Le Guern, Francine Behar-Cohen, Sophie Thevenin, Emmanuel Augé, Jessica Guillaume, Vivien Vasseur, Nathalie Costedoat-Chalumean

{"title":"\"En Face\" Spectral-Domain Optical Coherence Tomography versus Multifocal Electroretinogram in Hydroxychloroquine Retinopathy Screening.","authors":"Martine Mauget-Faÿsse, Georges Sukkarieh, Hajar Jebrane, Justine Lafolie, Anne Sophie Alonso, Elsa Laumonier, Sabine Derrien, Veronique Le Guern, Francine Behar-Cohen, Sophie Thevenin, Emmanuel Augé, Jessica Guillaume, Vivien Vasseur, Nathalie Costedoat-Chalumean","doi":"10.1159/000528146","DOIUrl":null,"url":null,"abstract":"Introduction: The performance of \"en face\" optical coherence tomography (OCT) in screening for chloroquine (CQ) or hydroxychloroquine (HCQ) retinopathy has not been largely explored. The aim of this study was to determine the concordance of \"en face\" OCT with multifocal electroretinography (mfERG) in screening for CQ/HCQ retinopathy.Methods: This is a prospective cohort study conducted at the Rothschild Foundation Hospital, Paris, between August 2016 and February 2021. Patients taking HCQ were followed up over 2 consecutive years and received an \"en face\" OCT and a mfERG on each visit.Results: A total of 91 patients (182 eyes) were analyzed. mfERG and \"en face\" OCT were concordant in 147 eyes (86.3%). Cohen's kappa coefficient for concordance between mfERG and \"en face\" OCT was considered weak with a value 0.61 (95% CI: 0.50-0.72). The sensitivity and specificity of \"en face\" OCT were 70% (95% CI: 59-79%) and 91% (95% CI: 83-96%), respectively, relatively to mfERG. Proportion of abnormal R2/R5 and R3/R5 ratios did not differ between patients with normal and abnormal \"en face\" OCT (p = 0.2).Discussion: \"En face\" OCT and mfERG have low concordance and cannot be used interchangeably as each investigation evaluates a different facet of CQ/HCQ retinopathy. \"En face\" OCT could be used as a complement in screening for CQ/HCQ retinal toxicity if the anomalies detected on \"en face\" OCT are confirmed by B-scan OCT sections.","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":"246 1","pages":"14-23"},"PeriodicalIF":2.1000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ophthalmologica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000528146","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: The performance of "en face" optical coherence tomography (OCT) in screening for chloroquine (CQ) or hydroxychloroquine (HCQ) retinopathy has not been largely explored. The aim of this study was to determine the concordance of "en face" OCT with multifocal electroretinography (mfERG) in screening for CQ/HCQ retinopathy.

Methods: This is a prospective cohort study conducted at the Rothschild Foundation Hospital, Paris, between August 2016 and February 2021. Patients taking HCQ were followed up over 2 consecutive years and received an "en face" OCT and a mfERG on each visit.

Results: A total of 91 patients (182 eyes) were analyzed. mfERG and "en face" OCT were concordant in 147 eyes (86.3%). Cohen's kappa coefficient for concordance between mfERG and "en face" OCT was considered weak with a value 0.61 (95% CI: 0.50-0.72). The sensitivity and specificity of "en face" OCT were 70% (95% CI: 59-79%) and 91% (95% CI: 83-96%), respectively, relatively to mfERG. Proportion of abnormal R2/R5 and R3/R5 ratios did not differ between patients with normal and abnormal "en face" OCT (p = 0.2).

Discussion: "En face" OCT and mfERG have low concordance and cannot be used interchangeably as each investigation evaluates a different facet of CQ/HCQ retinopathy. "En face" OCT could be used as a complement in screening for CQ/HCQ retinal toxicity if the anomalies detected on "en face" OCT are confirmed by B-scan OCT sections.

查看原文本刊更多论文

“En Face”光谱域光学相干断层扫描与多焦视网膜电图在羟氯喹视网膜病变筛查中的应用。

“正面”光学相干断层扫描(OCT)在筛查氯喹(CQ)或羟氯喹(HCQ)视网膜病变方面的表现尚未得到大量探索。本研究的目的是确定“面部”OCT与多焦视网膜电图(mfERG)在筛查CQ/HCQ视网膜病变中的一致性。方法:这是一项前瞻性队列研究，于2016年8月至2021年2月在巴黎罗斯柴尔德基金会医院进行。服用HCQ的患者连续随访2年以上，每次就诊均接受“正面”OCT和mfERG检查。结果:共分析91例患者(182只眼)。mfERG与“正面”OCT吻合147眼(86.3%)。mfERG与“正面”OCT之间一致性的Cohen’s kappa系数较弱，值为0.61 (95% CI: 0.50-0.72)。相对于mfERG，“正面”OCT的敏感性和特异性分别为70% (95% CI: 59-79%)和91% (95% CI: 83-96%)。“正面”OCT正常与异常患者的R2/R5、R3/R5异常比例无显著性差异(p = 0.2)。讨论:“En face”OCT和mfERG一致性较低，不能互换使用，因为每次调查评估的是CQ/HCQ视网膜病变的不同方面。如果“En face”OCT检测到的异常在b扫描OCT切片上得到证实，则“En face”OCT可作为CQ/HCQ视网膜毒性筛查的补充。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Ophthalmologica 医学-眼科学

CiteScore

5.10

自引率

3.80%

发文量

审稿时长

3 months

期刊介绍： Published since 1899, ''Ophthalmologica'' has become a frequently cited guide to international work in clinical and experimental ophthalmology. It contains a selection of patient-oriented contributions covering the etiology of eye diseases, diagnostic techniques, and advances in medical and surgical treatment. Straightforward, factual reporting provides both interesting and useful reading. In addition to original papers, ''Ophthalmologica'' features regularly timely reviews in an effort to keep the reader well informed and updated. The large international circulation of this journal reflects its importance.