Radiological Disease Activity in Secondary Progressive Multiple Sclerosis.

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

European Neurology Pub Date : 2023-01-01 DOI:10.1159/000527720

Daniela Noa Zohar, David Magalashvili, Sapir Dreyer-Alster, Chen Hoffmann, Gil Harari, Mark Dolev, Anat Achiron

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引用次数: 0

Abstract

Introduction: MRI activity is less frequent among secondary progressive multiple sclerosis (SPMS) patients. In the current study, we aimed to identify SPMS patients with higher radiological disease activity (RDA) and determine their clinical characteristics.

Methods: We evaluated the occurrence of RDA in SPMS patients followed at the Sheba Multiple Sclerosis Center between January 1, 2015, and December 31, 2020. All patients underwent brain and spinal cord MRI examinations as a routine follow-up unrelated to clinical disease activity. Patients were subdivided into RDA and non-RDA MRI groups based on the presence of active gadolinium-enhancing T1 lesions and/or new/enlarging T2 lesions. Demographic variables and disease-related data were compared.

Results: One hundred consecutive SPMS patients, 74 females, median age of 50 years, disease duration of 19.5 years, and neurological disability by the Expanded Disability Status Scale (EDSS) score of 6.0, were included in the study. The RDA group comprised 35 patients (35%), of them 65.7% (n = 23) exhibited only brain MRI activity, 22.8% (n = 8) only spinal cord MRI activity, and 11.4% (n = 4) had both. Patients in the RDA group were diagnosed at a younger mean (SD) age of 28.2 (8.9) versus 33.7 (10.1) years and were younger with a mean (SD) age of 47.8 (9.9) versus 53.4 (10.1) years, as compared with the non-RDA group. No significant differences were found in relation to disease duration, EDSS, exposure to immunomodulatory treatments, and duration of immunomodulatory treatments.

Conclusions: RDA unrelated to clinical symptomatology was more frequent in a subgroup of young SPMS patients.

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继发性进行性多发性硬化的放射学疾病活动性。

MRI活动在继发性进行性多发性硬化症(SPMS)患者中较少发生。在本研究中，我们旨在识别具有较高放射疾病活动性(RDA)的SPMS患者并确定其临床特征。方法:我们评估了2015年1月1日至2020年12月31日在Sheba多发性硬化症中心随访的SPMS患者的RDA发生情况。所有患者均接受脑和脊髓MRI检查，作为与临床疾病活动无关的常规随访。根据活动性钆增强T1病变和/或新发/扩大T2病变的存在，将患者细分为RDA和非RDA MRI组。比较人口学变量和疾病相关数据。结果:连续纳入100例SPMS患者，女性74例，中位年龄50岁，病程19.5年，扩展残疾状态量表(EDSS)评分6.0分神经功能障碍。RDA组35例患者(35%)，其中65.7% (n = 23)仅显示脑MRI活动，22.8% (n = 8)仅显示脊髓MRI活动，11.4% (n = 4)两者兼有。与非RDA组相比，RDA组患者的平均(SD)年龄更年轻，分别为28.2(8.9)岁和33.7(10.1)岁，平均(SD)年龄为47.8(9.9)岁和53.4(10.1)岁。在疾病持续时间、EDSS、免疫调节治疗暴露和免疫调节治疗持续时间方面没有发现显著差异。结论:与临床症状无关的RDA在年轻SPMS患者亚组中更为常见。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Neurology 医学-临床神经学

CiteScore

4.40

自引率

4.20%

发文量

审稿时长

4-8 weeks

期刊介绍： ''European Neurology'' publishes original papers, reviews and letters to the editor. Papers presented in this journal cover clinical aspects of diseases of the nervous system and muscles, as well as their neuropathological, biochemical, and electrophysiological basis. New diagnostic probes, pharmacological and surgical treatments are evaluated from clinical evidence and basic investigative studies. The journal also features original works and reviews on the history of neurology.