Parkinson's disease and cardiovascular involvement: Edifying insights (Review).

IF 2.3 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Biomedical reports Pub Date : 2023-02-14 eCollection Date: 2023-03-01 DOI:10.3892/br.2023.1607
Laura Grosu, Alin Ionut Grosu, Dana Crisan, Alexandru Zlibut, Lacramioara Perju-Dumbrava
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引用次数: 0

Abstract

Parkinson's disease (PD) is one of the most common neurodegenerative illnesses, and is a major healthcare burden with prodigious consequences on life-quality, morbidity, and survival. Cardiovascular diseases are the leading cause of mortality worldwide and growing evidence frequently reports their co-existence with PD. Cardiac dysautonomia due to autonomic nervous system malfunction is the most prevalent type of cardiovascular manifestation in these patients, comprising orthostatic and postprandial hypotension, along with supine and postural hypertension. Moreover, many studies have endorsed the risk of patients with PD to develop ischemic heart disease, heart failure and even arrhythmias, but the underlying mechanisms are not entirely clear. As importantly, the medication used in treating PD, such as levodopa, dopamine agonists or anticholinergic agents, is also responsible for cardiovascular adverse reactions, but further studies are required to elucidate the underlying mechanisms. The purpose of this review was to provide a comprehensive overview of current available data regarding the overlapping cardiovascular disease in patients with PD.

Abstract Image

Abstract Image

帕金森病与心血管疾病:启发性见解(综述)。
帕金森病(Parkinson's disease,PD)是最常见的神经退行性疾病之一,也是主要的医疗负担,对生活质量、发病率和存活率造成巨大影响。心血管疾病是导致全球死亡的主要原因,越来越多的证据显示心血管疾病与帕金森病同时存在。自律神经系统功能失调导致的心脏自律神经失调是这些患者最常见的心血管表现类型,包括直立性和餐后低血压,以及仰卧位和体位性高血压。此外,许多研究都认可肢端麻痹症患者有患缺血性心脏病、心力衰竭甚至心律失常的风险,但其潜在机制尚不完全清楚。同样重要的是,治疗帕金森病的药物,如左旋多巴、多巴胺受体激动剂或抗胆碱能药物,也是导致心血管不良反应的原因,但还需要进一步的研究来阐明其潜在机制。本综述旨在全面概述有关帕金森病患者重叠性心血管疾病的现有数据。
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来源期刊
Biomedical reports
Biomedical reports MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
4.10
自引率
0.00%
发文量
86
期刊介绍: Biomedical Reports is a monthly, peer-reviewed journal, dedicated to publishing research across all fields of biology and medicine, including pharmacology, pathology, gene therapy, genetics, microbiology, neurosciences, infectious diseases, molecular cardiology and molecular surgery. The journal provides a home for original research, case reports and review articles.
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