Gly-Pro-Val-Gly-Pro-Ser Peptide Fish Collagen Improves Skin Moisture and Wrinkles with Ameliorated the Oxidative Stress and Pro-inflammatory Factors in Skin Photoaging Mimic Models.

IF 1.6 Q3 FOOD SCIENCE & TECHNOLOGY
Wonhee Cho, Jeongjin Park, Minhee Lee, Seong-Hoo Park, Jaeeun Jung, Jinhak Kim, Sangwon Eun, Jinkyung Kim
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引用次数: 2

Abstract

This study aimed to investigate whether low molecular fish collagen peptide (FC) from Oreochromis niloticus had protective effects on skin of photoaging mimic models. We observed that FC supplementation improved antioxidant enzymes activities and regulated the pro-inflammatory cytokines [e.g., tumor necrosis factor-α, interleukin (IL)-1β, and IL-6] by reducing the protein expressions of pro-inflammatory factors IκBα, p65, and cyclooxygenase-2 in ultraviolet-B (UV-B) irradiated in vitro and in vivo. Furthermore, FC increased hyaluronic acid, sphingomyelin, and skin hydration by reg-ulating the mRNA expression of hyaluronic acid synthases 1∼3, serine palmitoyltransferase 1, delta 4-desaturase, sphingolipid 1, and protein expressions of ceramide synthase 4, matrix metalloproteinase (MMP)-1, -2, and -9. In UV-B irradiated in vitro and in vivo, FC down-regulated the protein expression of the c-Jun N-terminal kinase, c-Fos, c-Jun, and MMP pathways and up-reg-ulated that of the transforming growth factor-β receptor I, collagen type I, procollagen type I, and small mothers against decapentaplegic homolog pathways. Our results suggest that FC can be effective against UV-B induced skin photoaging by improving skin dryness and wrinkle formation through antioxidant and anti-inflammatory properties.

Gly-Pro-Val-Gly-Pro-Ser肽鱼胶原蛋白通过改善皮肤光老化模拟模型中的氧化应激和促炎因子,改善皮肤水分和皱纹。
本研究旨在探讨尼罗鱼低分子鱼胶原肽(FC)对光老化模拟模型皮肤的保护作用。我们观察到,在体外和体内紫外线照射下,补充FC通过降低促炎因子IκBα、p65和环氧化酶-2的蛋白表达,提高抗氧化酶活性,调节促炎因子[如肿瘤坏死因子-α、白细胞介素(IL)-1β和IL-6]。此外,FC通过调节透明质酸合成酶1 ~ 3、丝氨酸棕榈酰基转移酶1、δ 4-去饱和酶、鞘脂1的mRNA表达以及神经酰胺合成酶4、基质金属蛋白酶(MMP)-1、-2和-9的蛋白表达,增加了透明质酸、鞘磷脂和皮肤水合作用。在体外和体内UV-B照射下,FC下调了c-Jun n端激酶、c-Fos、c-Jun和MMP通路的蛋白表达,上调了转化生长因子-β受体I、I型胶原、I型前胶原和小母抗十肢瘫痪同源通路的蛋白表达。我们的研究结果表明,FC可以通过抗氧化和抗炎特性改善皮肤干燥和皱纹形成,有效对抗UV-B诱导的皮肤光老化。
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来源期刊
Preventive Nutrition and Food Science
Preventive Nutrition and Food Science Agricultural and Biological Sciences-Food Science
CiteScore
3.40
自引率
0.00%
发文量
35
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