Lower respiratory tract infections due to multi‑drug resistant pathogens in central nervous system injuries (Review).

IF 2.3 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Vasiliki Epameinondas Georgakopoulou, Aikaterini Gkoufa, Aikaterini Aravantinou-Fatorou, Ilias Trakas, Nikolaos Trakas, Konstantinos Faropoulos, Konstantinos Paterakis, George Fotakopoulos
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引用次数: 1

Abstract

Pneumonia is one of the most prevalent infections in the intensive care unit (ICU), where pneumonia may occur during hospitalization in the ICU as a complication. ICU patients with central nervous system (CNS) injuries are not an exception, and they may even be more susceptible to infections such as pneumonia due to issues such as swallowing difficulties, the requirement for mechanical ventilation, and extended hospital stay. Numerous common CNS injuries, such as ischemic stroke, traumatic brain injury, subarachnoid hemorrhage, and intracerebral hemorrhage, can prolong hospital stay and increase the risk of pneumonia. Multidrug-resistant (MDR) microorganisms are a common and significant concern, with increased mortality in nosocomial pneumonia. However, research on pneumonia due to MDR pathogens in patients with CNS injuries is limited. The aim of the present review was to provide the current evidence regarding pneumonia due to MDR pathogens in patients with CNS injuries. The prevalence of pneumonia due to MDR pathogens in CNS injuries differs among different settings, types of CNS injuries, geographical areas, and time periods in which the studies were performed. Specific risk factors for the emergence of pneumonia due to MDR pathogens have been identified in ICUs and neurological rehabilitation units. Antimicrobial resistance is currently a global issue, although using preventive measures, early diagnosis, and close monitoring of MDR strains may lessen its impact. Since there is a lack of information on these topics, more multicenter prospective studies are required to offer insights into the clinical features and outcomes of these patients.

Abstract Image

Abstract Image

中枢神经系统损伤中多重耐药病原菌引起的下呼吸道感染(综述)。
肺炎是重症监护病房(ICU)最常见的感染之一,在ICU住院期间,肺炎可能作为并发症发生。中枢神经系统(CNS)损伤的ICU患者也不例外,由于吞咽困难、需要机械通气和延长住院时间等问题,他们甚至更容易感染肺炎等感染。许多常见的中枢神经系统损伤,如缺血性中风、外伤性脑损伤、蛛网膜下腔出血和脑出血,可延长住院时间并增加肺炎的风险。耐多药(MDR)微生物是一种常见且重要的问题,在院内肺炎中死亡率增加。然而,对CNS损伤患者因耐多药病原菌引起的肺炎的研究有限。本综述的目的是为中枢神经系统损伤患者中耐多药病原体引起的肺炎提供目前的证据。在进行研究的不同环境、CNS损伤类型、地理区域和时间段中,多药耐药病原体引起的CNS损伤肺炎的流行率有所不同。在重症监护室和神经康复病房中已经确定了因耐多药病原体引起的肺炎的具体危险因素。抗菌素耐药性目前是一个全球性问题,尽管采取预防措施、早期诊断和密切监测耐多药菌株可能会减轻其影响。由于缺乏关于这些主题的信息,需要更多的多中心前瞻性研究来深入了解这些患者的临床特征和结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomedical reports
Biomedical reports MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
4.10
自引率
0.00%
发文量
86
期刊介绍: Biomedical Reports is a monthly, peer-reviewed journal, dedicated to publishing research across all fields of biology and medicine, including pharmacology, pathology, gene therapy, genetics, microbiology, neurosciences, infectious diseases, molecular cardiology and molecular surgery. The journal provides a home for original research, case reports and review articles.
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