Diet, nutrition and intestinal permeability: A mini review.

IF 1.3 4区 医学 Q4 NUTRITION & DIETETICS
Karina Rahmadia Ekawidyani, Murdani Abdullah
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引用次数: 1

Abstract

Background and objectives: Intestinal permeability (IP) is known to contribute to the immune system activation and inflammation; thus, it is proposed to have a role in the pathogenesis and exacerbation of many chronic diseases. Several studies have indicated that diet and nutritional status are risk factors for increased IP. In this mini review, we discussed the recent evidence on the association of diet, nutritional status, and intestinal permeability assessed by zonulin concentrations in serum and feces.

Methods and study design: Literature searching was conducted in Pubmed, ProQuest and Google Scholar using the keywords "diet quality", "intestinal permeability", "nutritional status", and "zonulin" combined with Boolean operators "AND" and "OR".

Results: Some studies indicated that intake of proper nutrition and good diet such as low total calorie intake, high intakes of omega-3 polyunsaturated fatty acids, fiber, vitamins, minerals, probiotics, and polyphenol-rich diet have significant impact on improvement of intestinal permeability marked by lower zonulin concentrations. Higher zonulin concentrations are found in those with overweight and obesity indicating that these population have increased IP. Most studies were conducted in adults and there are limited studies in children and adolescents. In addition, no studies have assessed diet quality to obtain a comprehensive picture on the complexities of diet in the population in relation to intestinal permeability.

Conclusions: Diet and nutritional status are linked to zonulin concentrations, indicating a role in intestinal permeability. Further research should be conducted to investigate the relationship between diet quality, as measured by appropriate diet quality indices, and intestinal permeability in children, adolescents, and adults.

饮食,营养和肠道通透性:一个小回顾。
背景和目的:众所周知,肠通透性(IP)与免疫系统激活和炎症有关;因此,它被认为在许多慢性疾病的发病和恶化中起作用。一些研究表明,饮食和营养状况是IP增加的危险因素。在这篇综述中,我们讨论了最近通过血清和粪便中的粪粘蛋白浓度评估的饮食、营养状况和肠道通透性之间关系的证据。方法与研究设计:以关键词“饮食质量”、“肠通透性”、“营养状况”、“zonulin”,结合布尔运算符“与”、“或”,在Pubmed、ProQuest、Google Scholar中进行文献检索。结果:一些研究表明,摄入适当的营养和良好的饮食,如低总热量摄入、高摄入omega-3多不饱和脂肪酸、纤维、维生素、矿物质、益生菌和富含多酚的饮食,对改善肠道通透性有显著影响,其显著特征是降低了zonulin浓度。在超重和肥胖人群中发现较高的zonulin浓度,表明这些人群的IP增加。大多数研究是在成人中进行的,对儿童和青少年的研究有限。此外,还没有研究评估饮食质量,以全面了解人群中饮食复杂性与肠道通透性的关系。结论:饮食和营养状况与zonulin浓度有关,表明在肠通透性中的作用。在儿童、青少年和成人中,应进一步研究饮食质量(以适当的饮食质量指标衡量)与肠道通透性之间的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.50
自引率
7.70%
发文量
58
审稿时长
6-12 weeks
期刊介绍: The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board
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