Protective Effects of Natural Polysaccharides on Intestinal Barrier Injury: A Review

IF 5.7 1区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of Agricultural and Food Chemistry Pub Date : 2022-01-04 DOI:10.1021/acs.jafc.1c05966

Jiaying Huo, Ziyan Wu, Weizheng Sun, Zhenhua Wang, Jihong Wu*, Mingquan Huang*, Bowen Wang, Baoguo Sun*

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引用次数: 45

Abstract

Owing to their minimal side effects and effective protection from oxidative stress, inflammation, and malignant growth, natural polysaccharides (NPs) are a potential adjuvant therapy for several diseases caused by intestinal barrier injury (IBI). More studies are accumulating on the protective effects of NPs with respect to IBI, but the underlying mechanisms remain unclear. Thus, this review aims to represent current studies that investigate the protective effects of NPs on IBI by directly maintaining intestinal epithelial barrier integrity (inhibiting oxidative stress, regulating inflammatory cytokine expression, and increasing tight junction protein expression) and indirectly regulating intestinal immunity and microbiota. Furthermore, the mechanisms underlying IBI development are briefly introduced, and the structure–activity relationships of polysaccharides with intestinal barrier protection effects are discussed. Potential developments and challenges associated with NPs exhibiting protective effects against IBI have also been highlighted to guide the application of NPs in the treatment of intestinal diseases caused by IBI.

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天然多糖对肠屏障损伤的保护作用研究进展

天然多糖(NPs)由于其最小的副作用和对氧化应激、炎症和恶性生长的有效保护，是肠屏障损伤(IBI)引起的几种疾病的潜在辅助治疗方法。关于NPs对IBI的保护作用的研究越来越多，但其潜在机制尚不清楚。因此，本综述旨在介绍目前研究NPs通过直接维持肠上皮屏障完整性(抑制氧化应激、调节炎症细胞因子表达、增加紧密连接蛋白表达)和间接调节肠道免疫和微生物群来研究其对IBI的保护作用。此外，本文还简要介绍了IBI发生的机制，并讨论了多糖与肠屏障保护作用的构效关系。还强调了NPs对IBI具有保护作用的潜在发展和挑战，以指导NPs在IBI引起的肠道疾病治疗中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Agricultural and Food Chemistry 农林科学-农业综合

CiteScore

9.90

自引率

8.20%

发文量

1375

审稿时长

2.3 months

期刊介绍： The Journal of Agricultural and Food Chemistry publishes high-quality, cutting edge original research representing complete studies and research advances dealing with the chemistry and biochemistry of agriculture and food. The Journal also encourages papers with chemistry and/or biochemistry as a major component combined with biological/sensory/nutritional/toxicological evaluation related to agriculture and/or food.