Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics

IF 45.8 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2023-02-23 DOI:10.1126/science.adc9998

Xenofon Strakosas, Hanne Biesmans, Tobias Abrahamsson, Karin Hellman, Malin Silverå Ejneby, Mary J. Donahue, Peter Ekström, Fredrik Ek, Marios Savvakis, Martin Hjort, David Bliman, Mathieu Linares, Caroline Lindholm, Eleni Stavrinidou, Jennifer Y. Gerasimov, Daniel T. Simon, Roger Olsson, Magnus Berggren

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引用次数: 19

Abstract

Interfacing electronics with neural tissue is crucial for understanding complex biological functions, but conventional bioelectronics consist of rigid electrodes fundamentally incompatible with living systems. The difference between static solid-state electronics and dynamic biological matter makes seamless integration of the two challenging. To address this incompatibility, we developed a method to dynamically create soft substrate-free conducting materials within the biological environment. We demonstrate in vivo electrode formation in zebrafish and leech models, using endogenous metabolites to trigger enzymatic polymerization of organic precursors within an injectable gel, thereby forming conducting polymer gels with long-range conductivity. This approach can be used to target specific biological substructures and is suitable for nerve stimulation, paving the way for fully integrated, in vivo–fabricated electronics within the nervous system.

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代谢物诱导的无基底有机生物电子器件的体内制造

将电子器件与神经组织连接起来对于了解复杂的生物功能至关重要，但传统的生物电子器件由刚性电极组成，与生物系统根本不兼容。静态固态电子元件与动态生物物质之间的差异使得两者之间的无缝整合极具挑战性。为了解决这种不兼容性，我们开发了一种在生物环境中动态创建无基底软导电材料的方法。我们在斑马鱼和水蛭模型中演示了体内电极的形成，利用内源性代谢物触发可注射凝胶中有机前体的酶聚合，从而形成具有远距离导电性的导电聚合物凝胶。这种方法可用于靶向特定的生物子结构，适用于神经刺激，为在神经系统内制造完全集成的体内电子器件铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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