Influence of Cardiovascular Risk Factors in Early Relapsing-Remitting Multiple Sclerosis: A Retrospective Analysis.

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

European Neurology Pub Date : 2023-01-01 DOI:10.1159/000527673

Pablo Arroyo-Pereiro, Albert Muñoz-Vendrell, Laura Bau, Elisabet Matas, Lucia Romero-Pinel, Antonio Martínez-Yélamos, Sergio Martínez-Yélamos

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引用次数: 0

Abstract

Introduction: Prior studies have suggested that cardiovascular risk factors (CVRFs) can affect the prognosis of multiple sclerosis (MS). The aim of this study was to assess if CVRFs affect the early course of MS.

Methods: A retrospective observational study was performed, including patients diagnosed with relapsing-remitting MS (RRMS) from 2010 to 2020, with at least 2 years of disease and 6 months follow-up. Age at onset, disease duration, number of relapses, time to confirmed Expanded Disability Status Scale (EDSS) 3.0 and 6.0, and time to secondary progressive MS (SPMS) were collected. Presence and date at onset of hypertension (HT), diabetes mellitus (DM), high low-density lipoprotein cholesterol (LDLc), and smoking during the study period were collected. The primary objective was to assess if CVRFs at the onset of MS are associated with lower time to EDSS 3.0, time to EDSS 6.0, and time to SPMS, using bivariate and multivariate analysis.

Results: 281 RRMS patients were included; median age at onset was 33 (IQR 26-39); 69.4% were female. Median EDSS at onset was 1.5 (IQR 1-2.5). Nine patients reached SPMS; 24 patients were diagnosed with HT, 9 with DM, 109 with high LDLc, and 123 were smokers during follow-up. No statistically significant association was found between the presence of CVRF at MS onset and the mentioned clinical outcomes during the MS course.

Conclusion: No association was found between CVRFs and the early course of MS in our cohort.

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心血管危险因素对早期复发-缓解型多发性硬化症的影响:回顾性分析

既往研究表明心血管危险因素(CVRFs)可影响多发性硬化症(MS)的预后。本研究的目的是评估cvrf是否影响MS的早期病程。方法:进行回顾性观察性研究，包括2010年至2020年诊断为复发-缓解型MS (RRMS)的患者，病程至少2年，随访6个月。收集发病年龄、病程、复发次数、确认扩展残疾状态量表(EDSS) 3.0和6.0的时间以及继发性进展性MS (SPMS)的时间。收集研究期间高血压(HT)、糖尿病(DM)、高低密度脂蛋白胆固醇(LDLc)和吸烟的存在和发病日期。主要目的是通过双变量和多变量分析，评估MS发病时cvrf是否与较短的EDSS 3.0时间、较短的EDSS 6.0时间和较短的SPMS时间相关。结果:纳入RRMS患者281例;发病年龄中位数为33岁(IQR 26-39);69.4%为女性。发病时平均EDSS为1.5 (IQR 1-2.5)。9例达到SPMS;随访期间，24例诊断为HT, 9例诊断为DM, 109例诊断为高ldl, 123例为吸烟者。在MS发病时CVRF的存在与MS病程中上述临床结果之间没有统计学意义的关联。结论:在我们的队列中，cvrf与MS的早期病程没有关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Neurology 医学-临床神经学

CiteScore

4.40

自引率

4.20%

发文量

审稿时长

4-8 weeks

期刊介绍： ''European Neurology'' publishes original papers, reviews and letters to the editor. Papers presented in this journal cover clinical aspects of diseases of the nervous system and muscles, as well as their neuropathological, biochemical, and electrophysiological basis. New diagnostic probes, pharmacological and surgical treatments are evaluated from clinical evidence and basic investigative studies. The journal also features original works and reviews on the history of neurology.