Integrin β1 and the Repair after Nervous System Injury.

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

European Neurology Pub Date : 2023-01-01 DOI:10.1159/000526690

Lei Yan, Zhiming Cui

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引用次数: 0

Abstract

Background: Integrin β1, as a member of the adhesion molecule family, is widely distributed in many kinds of cells and participates in multiple biological functions of the nervous system, including cytoskeleton reorganization, axon growth, and inflammatory injury.

Summary: After nervous system injury, integrin β1 expressed by microglia is mainly involved in promoting inflammatory damage; integrin β1 expressed by astrocytes plays an important role in axon regeneration; integrin β1 expressed by endothelial cells mainly participates in vascular remodeling. We concluded that the function of integrin β1 depends on the location of the receptor cells. The mechanism of integrin β1, which is involved in the inflammatory response of immune regulatory cells and affects the axonal regeneration of neuronal cells, is the key to explore the repair after nervous system injury. The development of drugs targeting integrin β1 is expected to bring a breakthrough in the treatment of nervous system injury.

Key messages: This paper expounds the important role of integrin β1 in neurons of the nervous system and emphasizes the central role of integrin β1 in regulating non-neuronal cells after nervous system damage.

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整合素β1与神经系统损伤后的修复。

背景:整合素β1作为粘附分子家族的成员，广泛分布于多种细胞中，参与神经系统的多种生物学功能，包括细胞骨架重组、轴突生长、炎症损伤等。摘要:神经系统损伤后，小胶质细胞表达整合素β1主要参与促进炎症损伤;星形胶质细胞表达的整合素β1在轴突再生中起重要作用;整合素β1主要由内皮细胞表达，参与血管重构。我们得出结论，整合素β1的功能取决于受体细胞的位置。整合素β1参与免疫调节细胞的炎症反应，影响神经元细胞轴突再生，其机制是探索神经系统损伤后修复的关键。靶向整合素β1药物的开发有望为神经系统损伤的治疗带来突破。本文阐述了整合素β1在神经系统神经元中的重要作用，强调了整合素β1在神经系统损伤后调节非神经元细胞中的核心作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Neurology 医学-临床神经学

CiteScore

4.40

自引率

4.20%

发文量

审稿时长

4-8 weeks

期刊介绍： ''European Neurology'' publishes original papers, reviews and letters to the editor. Papers presented in this journal cover clinical aspects of diseases of the nervous system and muscles, as well as their neuropathological, biochemical, and electrophysiological basis. New diagnostic probes, pharmacological and surgical treatments are evaluated from clinical evidence and basic investigative studies. The journal also features original works and reviews on the history of neurology.