Uric acid is negatively associated with cognition in the first- episode of schizophrenia

IF 1.2 4区医学 Q4 NEUROSCIENCES

Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique Pub Date : 2024-02-01 DOI:10.1016/j.encep.2023.01.006

W. Hu , B. Cheng , L. Su , J. Lv , J. Zhu

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引用次数: 0

Abstract

Background

We explored the relationship between levels of serum uric acid (UA) and cognitive impairment in people with schizophrenia to order to better protect and improve cognitive function in such patients.

Methods

A uricase method evaluated serum UA levels in 82 individuals with first-episode schizophrenia and in 39 healthy controls. The Brief Psychiatric Rating Scale (BPRS) and the event-related potential P300 were used to assess the patient's psychiatric symptoms and cognitive functioning. The link between serum UA levels, BPRS scores, and P300 was investigated.

Results

Prior to treatment, serum UA levels and latency N3 in the study group were significantly higher than in the control group, whereas the amplitude P3 was considerably lower. After therapy, the study group's BPRS scores, serum UA levels, latency N3, and amplitude P3 were lower than before treatment. According to correlation analysis, serum UA levels in the pre-treatment study group significantly positively correlated with BPRS score and latency N3 but not amplitude P3. After therapy, serum UA levels were no longer substantially related to the BPRS score or amplitude P3 but strongly and positively correlated with latency N3.

Conclusions

First-episode schizophrenia patients have higher serum UA levels than the general population which partly reflects poor cognitive performance. Improving patients’ cognitive function may be facilitated by lowering serum UA levels.

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尿酸与首次发作的精神分裂症患者的认知能力呈负相关

背景我们探讨了精神分裂症患者血清尿酸（UA）水平与认知功能障碍之间的关系，以便更好地保护和改善这类患者的认知功能。采用简明精神病评定量表（BPRS）和事件相关电位P300来评估患者的精神症状和认知功能。结果在治疗前，研究组的血清 UA 水平和潜伏期 N3 明显高于对照组，而振幅 P3 则明显低于对照组。治疗后，研究组的 BPRS 评分、血清 UA 水平、潜伏期 N3 和振幅 P3 均低于治疗前。根据相关性分析，治疗前研究组的血清 UA 水平与 BPRS 评分和潜伏期 N3 呈显著正相关，但与 P3 振幅无关。治疗后，血清 UA 水平与 BPRS 评分或 P3 振幅不再有实质性关系，但与潜伏期 N3 呈强正相关。降低血清 UA 水平有助于改善患者的认知功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Encephale-Revue De Psychiatrie Clinique Biologique et Therapeutique 医学-精神病学

CiteScore

4.60

自引率

7.40%

发文量

162

审稿时长

6-12 weeks

期刊介绍： Une revue française de renommée internationale. - Un comite de rédaction représentant tous les aspects de la prise en charge psychiatrique du patient. - Une sélection rigoureuse d''articles faisant l''objet de plusieurs expertises. - Des travaux d''auteurs et de chercheurs de renommée internationale. - Des indexations dans les grandes bases de données (Current Contents, Excerpta Medica, etc.). - Un facteur d''impact qui témoigne de la grande notoriété de la revue. La tribune des publications originales de haut niveau. - Une très grande diversité des sujets traités, rigoureusement sélectionnés à travers des sommaires dynamiques : - des éditoriaux de médecins référents, - une revue de presse sur les actualités internationales, - des articles originaux pour approfondir vos connaissances, - des mises au point et des cas cliniques pour engager votre réflexion sur les indications et choix possibles au travers de mises en situation clinique, - des dossiers thématiques pour faire le tour d''une question. - L''actualité de l''AFPB : L''Encéphale publie régulièrement des comptes rendus de l''Association française de psychiatrie clinique.