Implications of type 1 and type 2 taste receptors on obesity-induced inflammation

G. Y. Koh, Yu Wang
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引用次数: 1

Abstract

Obesity is characterized by chronic low-grade inflammation that could lead to the other health complications, such as cardiovascular disease, diabetes, and various cancers. Nutrient intake and dietary preferences are often modulated by taste receptors in the taste buds. Emerging evidence has shown that taste perception is altered during the development of obesity. It is demonstrated that suppression of taste receptor or taste signaling molecules can potentiate inflammatory response, whereas progressive inflammation has shown to attenuate the expression of taste receptors in vivo, which could be suggestive of an interplay between taste signaling and inflammation. This review summarizes the interactions between types 1 and 2 taste receptors and inflammation, as well as the impact of obesity on taste signaling. Taken together, taste receptors might play a crucial role in regulating the inflammatory response during obesity and hence may serve as a potential therapeutic target to prevent the progression of obesity.
1型和2型味觉受体对肥胖诱导炎症的影响
肥胖的特点是慢性低度炎症,可能导致其他健康并发症,如心血管疾病、糖尿病和各种癌症。营养摄入和饮食偏好通常是由味蕾中的味觉受体调节的。新出现的证据表明,在肥胖的发展过程中,味觉会发生改变。研究表明,味觉受体或味觉信号分子的抑制可以增强炎症反应,而体内的进行性炎症已经显示出味觉受体的表达减弱,这可能暗示了味觉信号和炎症之间的相互作用。本文综述了1型和2型味觉受体与炎症的相互作用,以及肥胖对味觉信号的影响。综上所述,味觉受体可能在调节肥胖期间的炎症反应中起着至关重要的作用,因此可能作为预防肥胖进展的潜在治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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