Programming circuitry for synthetic biology

IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2016-04-01 DOI:10.1126/SCIENCE.352.6281.48-L

L. Ray

引用次数: 1

Abstract

Synthetic Biology As synthetic biology techniques become more powerful, researchers are anticipating a future in which the design of biological circuits will be similar to the design of integrated circuits in electronics. Nielsen et al. describe what is essentially a programming language to design computational circuits in living cells. The circuits generated on plasmids expressed in Escherichia coli required careful insulation from their genetic context, but primarily functioned as specified. The circuits could, for example, regulate cellular functions in response to multiple environmental signals. Such a strategy can facilitate the development of more complex circuits by genetic engineering. Science , this issue p. [10.1126/science.aac7341][1] [1]: /lookup/doi/10.1126/science.aac7341

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合成生物学的编程电路

合成生物学随着合成生物学技术变得越来越强大，研究人员预计未来生物电路的设计将类似于电子学中的集成电路的设计。Nielsen等人描述了什么本质上是一种编程语言来设计活细胞中的计算电路。在大肠杆菌中表达的质粒上产生的电路需要与它们的遗传环境小心地隔离，但主要是按照规定的功能。例如，这种电路可以根据多种环境信号调节细胞功能。这种策略可以通过基因工程促进更复杂电路的发展。《科学》，本期p. [10.1126/ Science]。[1] [1]: /lookup/doi/10.1126/science.aac7341

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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