Cryptotanshinone From Salvia miltiorrhiza Inhibits the Growth of Tumors and Enhances the Efficacy of Chemotherapy in a Gastric Cancer Mouse Model

IF 1.4 4区医学 Q4 CHEMISTRY, MEDICINAL

Natural Product Communications Pub Date : 2022-10-01 DOI:10.1177/1934578X221130874

Wen-qi Wu, Yezhi Cao, Ling Cheng, Linghu Wang, Qingsheng Yu, Hui Peng, F. Zhou, Haiwei Liu, Qi Zhang

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引用次数: 4

Abstract

Cryptotanshinone is a quinone diterpene extracted from the traditional Chinese medicine Salvia miltiorrhiza root that shows obvious anticancer activity. The aim of this study was to investigate the mechanism of action of cryptotanshinone as an antigastric cancer agent, as well as a chemotherapy potentiator. A gastric cancer model was established by tumor transplantation, and mice were treated with either 5-fluorouracil or cryptotanshinone, or both drugs. The tumor mass was recorded, and the tumor suppression rate was calculated. Pathological changes were observed by hematoxylin and eosin staining, gene transcription was detected by quantitative polymerase chain reaction, and protein expression by Western blotting. The results showed that cryptotanshinone could reduce the tumor mass, increase the tumor suppression rate, and enhance the chemotherapeutic effect of 5-fluorouracil by a mechanism related to inhibition of the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway.

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丹参隐丹参酮在胃癌小鼠模型中抑制肿瘤生长并提高化疗疗效

隐丹参酮是从中药丹参中提取的一种醌类二萜，具有明显的抗癌活性。本研究旨在探讨隐丹参酮作为抗胃癌药物和化疗增强剂的作用机制。采用肿瘤移植建立胃癌模型，小鼠分别给予5-氟尿嘧啶或隐丹参酮或两种药物治疗。记录肿瘤体积，计算肿瘤抑制率。苏木精和伊红染色观察病理变化，定量聚合酶链反应检测基因转录，Western blotting检测蛋白表达。结果表明，隐丹参酮可通过抑制Janus kinase 2/信号转导因子和转录3信号通路激活因子的作用，降低肿瘤体积，提高肿瘤抑制率，增强5-氟尿嘧啶的化疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Communications 工程技术-食品科技

CiteScore

3.10

自引率

11.10%

发文量

254

审稿时长

2.7 months

期刊介绍： Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products. Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products. Natural Product Communications is a peer reviewed, open access journal studying all aspects of natural products, including isolation, characterization, spectroscopic properties, biological activities, synthesis, structure-activity, biotransformation, biosynthesis, tissue culture and fermentation. It covers the full breadth of chemistry, biochemistry, biotechnology, pharmacology, and chemical ecology of natural products.