Repetitive Transcranial Magnetic Stimulation Improves Hippocampal N-Acetlaspartate Levels and Visual Memory Scores in Alzheimer's Disease.

IF 1 4区医学 Q4 CLINICAL NEUROLOGY

Noropsikiyatri Arsivi-Archives of Neuropsychiatry Pub Date : 2024-06-01 eCollection Date: 2024-01-01 DOI:10.29399/npa.28420

Halil Aziz Velioğlu, Dila Sayman, Lütfü Hanoğlu, Gülhan Ertan Akan, Şeyda Çankaya, Burak Yuluğ

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引用次数: 0

Abstract

The latest research into the pathophysiology of Alzheimer's Disease (AD) has included several cognitive deficits related to hippocampal functioning. However, current clinical research fails to consider the full extent of the heterogeneous cognitive spectrum of AD, resulting in a lack of the specific methods required to draw definitive diagnostic and therapeutic conclusions. This also includes in-vivo metabolic measurements for tailoring the diagnostic and therapeutic regimens in humans with AD. Magnetic resonance spectroscopy and repetitive transcranial magnetic stimulation (rTMS) are two novel diagnostic and therapeutic approaches that must be modified to treat AD. In the present study, we aimed to investigate the underlying therapeutic role of rTMS in humans with AD by evaluating the in-vivo hippocampal metabolites before and after rTMS treatment. Based on the data obtained using the fMRI data in our previous study and on the references reported in the literature, in the present study, we decided to use hippocampal NAA data after rTMS stimulation and found a significant increase in NAA levels. To the best of our knowledge, no other study has evaluated the effect of rTMS on hippocampal metabolites in humans with AD.

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重复经颅磁刺激可改善阿尔茨海默氏症患者的海马体 N-乙酰天冬氨酸水平和视觉记忆评分。

对阿尔茨海默病（AD）病理生理学的最新研究包括与海马功能有关的几种认知障碍。然而，目前的临床研究未能全面考虑阿尔茨海默病的各种认知谱系，导致缺乏得出明确诊断和治疗结论所需的特定方法。这其中也包括体内代谢测量，以调整 AD 患者的诊断和治疗方案。磁共振波谱分析和重复经颅磁刺激（rTMS）是两种新的诊断和治疗方法，必须对其进行修改以治疗 AD。在本研究中，我们旨在通过评估经颅磁刺激治疗前后的体内海马代谢物，研究经颅磁刺激对 AD 患者的潜在治疗作用。根据我们之前研究中使用 fMRI 数据获得的数据以及文献中的参考文献，我们决定在本研究中使用经颅磁刺激后的海马 NAA 数据，结果发现 NAA 水平显著增加。据我们所知，还没有其他研究评估过经颅磁刺激对AD患者海马代谢物的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Noropsikiyatri Arsivi-Archives of Neuropsychiatry CLINICAL NEUROLOGY-

CiteScore

1.70

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Archives of Neuropsychiatry (Arch Neuropsychiatry) is the official journal of the Turkish Neuropsychiatric Society. It is published quarterly, and four editions annually constitute a volume. Archives of Neuropsychiatry is a peer reviewed scientific journal that publishes articles on psychiatry, neurology, and behavioural sciences. Both clinical and basic science contributions are welcomed. Submissions that address topics in the interface of neurology and psychiatry are encouraged. The content covers original research articles, reviews, letters to the editor, and case reports.