One receptor, two worlds: MXRA8's alphavirus tango.

James Weger-Lucarelli
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Abstract

Mammalian MXRA8 functions as a receptor for chikungunya and other related alphaviruses. A recent study in Cell molecularly characterizes host-specific receptor usage, specifically showing avian MXRA8 acts as a receptor for several alphaviruses with avian reservoirs in an inverted manner relative to alphaviruses that use mammalian MXRA8 as a receptor.

一个受体,两个世界:MXRA8的阿尔法病毒探戈。
哺乳动物MXRA8作为基孔肯雅病毒和其他相关α病毒的受体发挥作用。《细胞》杂志最近的一项研究对宿主特异性受体的使用进行了分子表征,特别表明与使用哺乳动物MXRA8作为受体的α病毒相比,鸟类MXRA8以相反的方式作为具有鸟类宿主的几种α病毒的受体。
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