Isolation and Structure Determination of Akunolides, Macrolide Glycosides from a Marine Okeania sp. Cyanobacterium

IF 3.3 2区生物学 Q2 CHEMISTRY, MEDICINAL

Journal of Natural Products Pub Date : 2023-11-09 DOI:10.1021/acs.jnatprod.3c00742

Kairi Umeda, Arihiro Iwasaki*, Raimu Taguchi, Naoaki Kurisawa, Ghulam Jeelani, Tomoyoshi Nozaki and Kiyotake Suenaga*,

引用次数: 0

Abstract

Akunolides A (1), B (2), C (3), and D (4), new macrolide glycosides, were isolated from a marine Okeania sp. cyanobacterium. Their structures were elucidated by spectroscopic analyses and derivatization reactions. Akunolides A–D (1–4) are classified as 16-membered macrolide glycosides, which are relatively rare structures for marine cyanobacterium-derived natural products. Akunolides A–D (1–4) showed moderate antitrypanosomal activities against Trypanosoma brucei rhodesiense, with IC₅₀ values ranging from 11 to 14 μM. Furthermore, akunolides A (1) and C (3) exhibited no cytotoxicity against normal human WI-38 cells even at a concentration of 150 μM.

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海洋Okeania sp.蓝藻中Akunolides和大环内酯糖苷的分离和结构测定。

从一株海生Okeania sp.蓝细菌中分离到新的大环内酯糖苷Akunolides A（1）、B（2）、C（3）和D（4）。通过光谱分析和衍生反应阐明了它们的结构。Akunolides A-D（1-4）被归类为16元大环内酯糖苷，这是海洋蓝藻衍生的天然产物中相对罕见的结构。Akunolides A-D（1-4）对布氏锥虫具有中等的抗锥虫活性，IC50值在11-14μM之间。此外，即使在150μM的浓度下，阿库内酯A（1）和C（3）对正常人WI-38细胞也没有表现出细胞毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.