Recent Developments in Blood Biomarkers in Neuro-oncology.

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY

Current Neurology and Neuroscience Reports Pub Date : 2023-12-01 Epub Date: 2023-11-09 DOI:10.1007/s11910-023-01321-y

Jessica B Foster, Mateusz P Koptyra, Stephen J Bagley

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引用次数: 0

Abstract

Purpose of review: Given the invasive and high-risk nature of brain surgery, the need for non-invasive biomarkers obtained from the peripheral blood is greatest in tumors of the central nervous system (CNS). In this comprehensive review, we highlight recent advances in blood biomarker development for adult and pediatric brain tumors.

Recent findings: We summarize recent blood biomarker development for CNS tumors across multiple key analytes, including peripheral blood mononuclear cells, cell-free DNA, cell-free RNA, proteomics, circulating tumor cells, and tumor-educated platelets. We also discuss methods for enhancing blood biomarker detection through transient opening of the blood-brain barrier. Although blood-based biomarkers are not yet used in routine neuro-oncology practice, this field is advancing rapidly and holds great promise for improved and non-invasive management of patients with brain tumors. Prospective and adequately powered studies are needed to confirm the clinical utility of any blood biomarker prior to widespread clinical implementation.

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血液生物标志物在神经肿瘤学中的最新进展。

综述目的：鉴于脑外科手术的侵入性和高风险性，对从外周血中获得的非侵入性生物标志物的需求在中枢神经系统（CNS）肿瘤中最大。在这篇全面的综述中，我们强调了成人和儿童脑肿瘤血液生物标志物开发的最新进展。最近的发现：我们总结了多种关键分析物中中枢神经系统肿瘤的最新血液生物标志物开发，包括外周血单核细胞、无细胞DNA、无细胞RNA、蛋白质组学、循环肿瘤细胞和受肿瘤影响的血小板。我们还讨论了通过短暂打开血脑屏障来增强血液生物标志物检测的方法。尽管基于血液的生物标志物尚未用于常规神经肿瘤学实践，但该领域进展迅速，有望改善脑肿瘤患者的非侵入性管理。在广泛临床应用之前，需要进行前瞻性和充分的研究来确认任何血液生物标志物的临床效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Neurology and Neuroscience Reports 医学-临床神经学

CiteScore

9.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Neurology and Neuroscience Reports provides in-depth review articles contributed by international experts on the most significant developments in the field. By presenting clear, insightful, balanced reviews that emphasize recently published papers of major importance, the journal elucidates current and emerging approaches to the diagnosis, treatment, management, and prevention of neurological disease and disorders. Presents the views of experts on current advances in neurology and neuroscience Gathers and synthesizes important recent papers on the topic Includes reviews of recently published clinical trials, valuable web sites, and commentaries from well-known figures in the field.