Stent composition and immune response after long-term coronary angioplasty.

IF 2.2 4区医学 Q3 PHYSIOLOGY

Physiology international Pub Date : 2023-11-07 Print Date: 2023-12-18 DOI:10.1556/2060.2023.00162

Viviane A R Sant'Anna, Adriano H P Barbosa, Rodrigo A Souza, José M A Sousa, Frederico Monfardini, Magnus Gidlund, Henrique A R Fonseca

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引用次数: 0

Abstract

Background: There are limited data about the influence of stent composition on immune responses after percutaneous coronary intervention (PCI).

Objective: The aim was to compare the effects of PCI with conventional cobalt-chromium bare metal stent (BMS) and drug-eluting stent (DES) implantation on the modulation of humoral and cellular immune responses.

Methods: A randomised, single-centre, open pilot study involving patients with stable coronary artery disease eligible for PCI was performed. Blood samples were collected from the peripheral artery (PA) and the coronary sinus (CS) at baseline and 40 weeks following PCI. IgM and IgG autoantibodies (Abs), anti-oxLDL and anti-ApoB-D, as well as cytokine levels were evaluated by enzyme-linked immunosorbent assay.

Results: A total of 30 patients of 60 years mean age were included, 68% of whom were men. At the nine-month follow-up, a modulation in the levels of cytokines and autoantibodies was observed in both stent type groups. However, no difference was observed in the modulation of these markers between stents.

Conclusion: The stent type promotes modulations in cellular and humoral immune responses in the long-term, with differences in the magnitude of effects in specific immune responses.

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支架成分与长期冠状动脉血管成形术后的免疫反应。

背景：关于支架成分对经皮冠状动脉介入治疗（PCI）后免疫反应的影响的数据有限。目的：比较PCI与传统钴铬裸金属支架（BMS）和药物洗脱支架（DES）植入对体液和细胞免疫反应的调节作用。方法：对符合PCI条件的稳定型冠状动脉疾病患者进行随机、单中心、开放性试点研究。在基线和PCI后40周从外周动脉（PA）和冠状窦（CS）采集血样。通过酶联免疫吸附试验评估IgM和IgG自身抗体（Abs）、抗oxLDL和抗ApoB-D以及细胞因子水平。结果：共纳入30名平均年龄为60岁的患者，其中68%为男性。在9个月的随访中，在两个支架型组中都观察到细胞因子和自身抗体水平的调节。然而，在支架之间这些标记物的调节没有观察到差异。结论：支架类型长期促进细胞和体液免疫反应的调节，在特异性免疫反应中的作用程度不同。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physiology international Medicine-Physiology (medical)

CiteScore

3.40

自引率

0.00%

发文量

期刊介绍： The journal provides a forum for important new research papers written by eminent scientists on experimental medical sciences. Papers reporting on both original work and review articles in the fields of basic and clinical physiology, pathophysiology (from the subcellular organization level up to the oranizmic one), as well as related disciplines, including history of physiological sciences, are accepted.