Perceived plausibility modulates hippocampal activity in episodic counterfactual thinking

IF 2.4 3区 医学 Q3 NEUROSCIENCES
Hippocampus Pub Date : 2023-10-31 DOI:10.1002/hipo.23583
Kaylee Miceli, Ricardo Morales-Torres, Ari Khoudary, Leonard Faul, Natasha Parikh, Felipe De Brigard
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引用次数: 0

Abstract

Episodic counterfactual thinking (ECT) consists of imagining alternative outcomes to past personal events. Previous research has shown that ECT shares common neural substrates with episodic future thinking (EFT): our ability to imagine possible future events. Both ECT and EFT have been shown to critically depend on the hippocampus, and past research has explored hippocampal engagement as a function of the perceived plausibility of an imagined future event. However, the extent to which the hippocampus is modulated by perceived plausibility during ECT is unknown. In this study, we combine two functional magnetic resonance imaging datasets to investigate whether perceived plausibility modulates hippocampal activity during ECT. Our results indicate that plausibility parametrically modulates hippocampal activity during ECT, and that such modulation is confined to the left anterior portion of the hippocampus. Moreover, our results indicate that this modulation is positive, such that increased activity in the left anterior hippocampus is associated with higher ratings of ECT plausibility. We suggest that neither effort nor difficulty alone can account for these results, and instead suggest possible alternatives to explain the role of the hippocampus during the construction of plausible and implausible ECT.

感知合理性在情景反事实思维中调节海马活动。
情节反事实思维(ECT)包括想象过去个人事件的替代结果。先前的研究表明,ECT与情景未来思维(EFT)有着共同的神经基础:我们想象未来可能事件的能力。ECT和EFT都被证明严重依赖于海马体,过去的研究已经探索了海马体参与作为想象中的未来事件的感知合理性的函数。然而,在ECT过程中,海马体在多大程度上受到感知合理性的调节尚不清楚。在这项研究中,我们将两个功能性磁共振成像数据集结合起来,研究ECT过程中感知的合理性是否调节海马活动。我们的研究结果表明,在ECT过程中,合理性参数性地调节海马活动,并且这种调节仅限于海马的左前部。此外,我们的研究结果表明,这种调节是积极的,因此左前海马活动的增加与ECT合理性的更高评级有关。我们认为,无论是努力还是困难都不能单独解释这些结果,相反,我们提出了可能的替代方案来解释海马体在构建可信和不可信ECT过程中的作用。
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来源期刊
Hippocampus
Hippocampus 医学-神经科学
CiteScore
5.80
自引率
5.70%
发文量
79
审稿时长
3-8 weeks
期刊介绍: Hippocampus provides a forum for the exchange of current information between investigators interested in the neurobiology of the hippocampal formation and related structures. While the relationships of submitted papers to the hippocampal formation will be evaluated liberally, the substance of appropriate papers should deal with the hippocampal formation per se or with the interaction between the hippocampal formation and other brain regions. The scope of Hippocampus is wide: single and multidisciplinary experimental studies from all fields of basic science, theoretical papers, papers dealing with hippocampal preparations as models for understanding the central nervous system, and clinical studies will be considered for publication. The Editor especially encourages the submission of papers that contribute to a functional understanding of the hippocampal formation.
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