Occurrence and Release of Organophosphite Antioxidants and Novel Organophosphate Esters from Plastic Food Packaging

Abstract

Organic phosphite antioxidants (OPAs) are widely added in plastic products and can be oxidized to generate oxidized derivatives (OPAs = O), namely organic phosphate esters (OPEs), during production and use processing. Herein, the occurrence of OPEs and OPAs in five plastic food packages was detected by liquid chromatography–tandem mass spectrometry. Three OPEs (TPhP, TCEP, and AO168 = O) and three OPAs (TPhPi, TCEPi, and AO168) were found in the plastic packages, with concentrations of <MQL-124 ng/g (∑₃OPAs) and 196–831 ng/g (∑₃OPEs), respectively. The migration potential of OPAs and OPEs to food was measured by simulation experiments. OPAs and OPEs in plastic can efficiently migrate to oily simulants, alkaline simulants, and acidic simulants. After 14 days, the total concentration of all OPAs and OPEs in the food simulants reached <MQL-1.21 (acidic food simulants), <MQL-0.32 (alkaline food simulants), and 11.4–31.4 ng/mL (oily food simulants), respectively. OPAs and OPEs in 12 kinds of plastic-packaged foods were detected, with high concentrations in dairy food (∑₃OPAs + ∑₃OPEs: 18.3–28.9 ng/mL) and in oils (∑₃OPAs + ∑₃OPEs: 32.7–60.9 ng/mL). Accordingly, the estimated ingestion of OPAs and OPEs through plastic-packaged food can reach 2.6 and 32.7 ng/kg in children and 1.1 and 6.5 ng/kg in adults, indicating a non-negligible exposure risk of organic phosphorus pollutants.