Highly Sensitive, Low Operating Power Cardiac Troponin Biosensor Using PANI Nanofiber OFET

IF 2.1 4区工程技术 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC

IEEE Transactions on Nanotechnology Pub Date : 2023-09-07 DOI:10.1109/TNANO.2023.3312819

Amira Ali;Abdelsattar M. Sallam;M. Mohsen;Amal Kasry;Sameh O. Abdellatif

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引用次数: 0

Abstract

Cardiovascular diseases (CVDs) are the leading cause of death worldwide, killing over 17 million people yearly. A key biomarker for identifying myocardial infarction (MI) is the regulatory protein Cardiovascular Troponin I (cTnI), released into the blood following heart muscle injury. Significant efforts have been made in recent years to develop highly sensitive biosensors for the detection of cTnI. Field effect transistors (FETs) in general and organic FETs (OFETs) in specific have shown computability in detecting such cordial protein. In this study, we provide a complete attempt to fabricate and characterize polyaniline nanofiber (PANI-NFs) OFET for biosensing applications. The FTIR spectrum of PANI-NFs is examined before and after pAbs immobilization. To study the biosensor performance parameters, the biomarker drain current is investigated against the cTnI biomarker concentrations. The proposed OFET recorded high sensitivity of 484 nA.(g/mL) ⁻¹ , with a minimum detection limit (0.36 pg/mL) and power consumption varying from 7 μW to 11.4 μW. Finally, the biosensing repeatability was examined regarding variation in the P-FET device and the biasing conditions.

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基于聚苯胺纳米纤维OFET的高灵敏度、低工作功率心脏肌钙蛋白生物传感器

心血管疾病是世界范围内的主要死亡原因，每年造成1700多万人死亡。识别心肌梗死(MI)的关键生物标志物是调节蛋白心血管肌钙蛋白I (cTnI)，在心肌损伤后释放到血液中。近年来，人们在开发高灵敏度的cTnI检测生物传感器方面做出了巨大的努力。一般的场效应晶体管(fet)和特定的有机场效应晶体管(ofet)在检测这类诚恳蛋白方面显示出可计算性。在这项研究中，我们为生物传感应用的聚苯胺纳米纤维(PANI-NFs) OFET的制备和表征提供了一个完整的尝试。研究了pAbs固定前后PANI-NFs的FTIR光谱。为了研究生物传感器的性能参数，研究了生物标志物漏极电流与cTnI生物标志物浓度的关系。该OFET的灵敏度为484 nA.(g/mL)−1，最低检测限为0.36 pg/mL，功耗为7 μW ~ 11.4 μW。最后，研究了P-FET器件和偏置条件的变化对生物传感重复性的影响。

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来源期刊

IEEE Transactions on Nanotechnology 工程技术-材料科学：综合

CiteScore

4.80

自引率

8.30%

发文量

审稿时长

8.3 months

期刊介绍： The IEEE Transactions on Nanotechnology is devoted to the publication of manuscripts of archival value in the general area of nanotechnology, which is rapidly emerging as one of the fastest growing and most promising new technological developments for the next generation and beyond.