Word finding, prosody and social cognition in multiple sclerosis

IF 2 4区心理学 Q2 PSYCHOLOGY

Journal of Neuropsychology Pub Date : 2022-07-12 DOI:10.1111/jnp.12285

Siew Mei Yap, Laura Davenport, Clodagh Cogley, Fiona Craddock, Alex Kennedy, Maria Gaughan, Hugh Kearney, Niall Tubridy, Céline De Looze, Fiadhnait O’Keeffe, Richard B. Reilly, Christopher McGuigan

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引用次数: 3

Abstract

Background

Impairments in speech and social cognition have been reported in people with multiple sclerosis (pwMS), although their relationships with neuropsychological outcomes and their clinical utility in MS are unclear.

Objectives

To evaluate word finding, prosody and social cognition in pwMS relative to healthy controls (HC).

Methods

We recruited people with relapsing MS (RMS, n = 21), progressive MS (PMS, n = 24) and HC (n = 25) from an outpatient MS clinic. Participants completed a battery of word-finding, social cognitive, neuropsychological and clinical assessments and performed a speech task for prosodic analysis.

Results

Of 45 pwMS, mean (SD) age was 49.4 (9.4) years, and median (range) Expanded Disability Severity Scale score was 3.5 (1.0–6.5). Compared with HC, pwMS were older and had slower information processing speed (measured with the Symbol Digit Modalities Test, SDMT) and higher depression scores. Most speech and social cognitive measures were associated with information processing speed but not with depression. Unlike speech, social cognition consistently correlated with intelligence and memory. Visual naming test mean response time (VNT-MRT) demonstrated worse outcomes in MS versus HC (p = .034, Nagelkerke’s R² = 65.0%), and in PMS versus RMS (p = .009, Nagelkerke’s R² = 50.2%). Rapid automatised object naming demonstrated worse outcomes in MS versus HC (p = .014, Nagelkerke’s R² = 49.1%). These word-finding measures showed larger effect sizes than that of the SDMT (MS vs. HC, p = .010, Nagelkerke’s R² = 40.6%; PMS vs. RMS, p = .023, Nagelkerke’s R² = 43.5%). Prosody and social cognition did not differ between MS and HC.

Conclusions

Word finding, prosody and social cognition in MS are associated with information processing speed and largely independent of mood. Impairment in visual object meaning perception is potentially a unique MS disease-related deficit that could be further explored and cautiously considered as an adjunct disability metric for MS.

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多发性硬化症的词汇发现、韵律与社会认知

语言和社会认知障碍在多发性硬化症(pwMS)患者中有报道，尽管它们与神经心理学结果的关系及其在多发性硬化症中的临床应用尚不清楚。目的比较pwMS患者与健康对照组的词汇发现、韵律和社会认知能力。方法我们从MS门诊招募复发性MS (RMS, n = 21)、进行性MS (PMS, n = 24)和HC (n = 25)患者。参与者完成了一系列词汇发现、社会认知、神经心理学和临床评估，并完成了韵律分析的语音任务。结果45例pwMS患者的平均(SD)年龄为49.4(9.4)岁，扩展残疾严重程度量表评分中位数(范围)为3.5(1.0-6.5)。与HC相比，pwMS年龄更大，信息处理速度更慢(用符号数字模态测试，SDMT测量)，抑郁评分更高。大多数言语和社会认知测试与信息处理速度有关，但与抑郁无关。与语言不同，社会认知始终与智力和记忆相关。视觉命名测试平均反应时间(VNT-MRT)显示MS比HC的结果更差(p =。034, Nagelkerke’s R2 = 65.0%)， PMS与RMS比较(p =。009, Nagelkerke’s R2 = 50.2%)。快速自动化对象命名在MS和HC中表现出更差的结果(p =。014, Nagelkerke’s R2 = 49.1%)。这些词查找测量比SDMT显示更大的效应量(MS vs. HC, p =)。010, Nagelkerke’s R2 = 40.6%;PMS vs. RMS, p =。023, Nagelkerke’s R2 = 43.5%)。韵律和社会认知在MS和HC之间没有差异。结论多发性硬化症患者的词语发现、韵律和社会认知与信息加工速度有关，且与情绪无关。视觉客体的损伤意味着感知可能是一种独特的多发性硬化症相关缺陷，可以进一步探索并谨慎考虑作为多发性硬化症的辅助残疾指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuropsychology 医学-心理学

CiteScore

4.50

自引率

4.50%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Neuropsychology publishes original contributions to scientific knowledge in neuropsychology including: • clinical and research studies with neurological, psychiatric and psychological patient populations in all age groups • behavioural or pharmacological treatment regimes • cognitive experimentation and neuroimaging • multidisciplinary approach embracing areas such as developmental psychology, neurology, psychiatry, physiology, endocrinology, pharmacology and imaging science The following types of paper are invited: • papers reporting original empirical investigations • theoretical papers; provided that these are sufficiently related to empirical data • review articles, which need not be exhaustive, but which should give an interpretation of the state of research in a given field and, where appropriate, identify its clinical implications • brief reports and comments • case reports • fast-track papers (included in the issue following acceptation) reaction and rebuttals (short reactions to publications in JNP followed by an invited rebuttal of the original authors) • special issues.