Triquinane Sesquiterpene Glycosides from the Basidiomycete Antrodiella zonata
IF 3.3
2区 生物学
Q2 CHEMISTRY, MEDICINAL
引用次数: 0
Abstract
In our ongoing study of fungal bioactive natural products, 12 previously undescribed triquinane sesquiterpene glycosides, namely, antrodizonatins A–L (1–12), and four known compounds (13–16) have been obtained from the fermentation of the basidiomycete Antrodiella zonata. The structures were established unambiguously via extensive spectroscopic analysis and theoretical calculations of electronic circular dichroism spectra. This is the first report of triquinane sesquiterpene glycosides. Compounds 1, 5, and 12 displayed antibacterial activity against Staphylococcus aureus with MIC50 values of 35, 34, and 69 μM, respectively.
担子菌Antrodiella zonata的三醌倍半萜苷
在我们正在进行的真菌生物活性天然产物的研究中，从担子菌Antrodiella zonata发酵中获得了12种以前未描述的三醌倍半萜苷，即antrodionatins A-L(1-12)和4种已知化合物(13-16)。通过广泛的光谱分析和电子圆二色光谱的理论计算，明确了这些结构。这是有关三奎宁倍半萜苷类化合物的首次报道。化合物1、5和12对金黄色葡萄球菌具有抗菌活性，其MIC50值分别为35、34和69 μM。
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来源期刊
CiteScore
9.10
自引率
5.90%
发文量
294
审稿时长
2.3 months
期刊介绍：
The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
When new compounds are reported, manuscripts describing their biological activity are much preferred.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
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