Phytochemical composition, anti-amylase and anti-acetylcholinesterase activities of leaf extracts and herbal tea of Dolichandrone serrulata (DC.) seem

IF 4.1 Q2 FOOD SCIENCE & TECHNOLOGY

NFS Journal Pub Date : 2023-09-27 DOI:10.1016/j.nfs.2023.100152

Sirikul Thummajitsakul , Kullanat Nattee , Pornapa Nathunli , Chompoonick Promprieng , Rujisaya Anekwasinchai , Kun Silprasit

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Abstract

The number of elderly population is continually growing in Thailand. Major health problems mostly occurred in the elder are non-communicable diseases namely Alzheimer's disease and type 2 diabetes mellitus. In current study, phytochemical composition, anti-amylase and anti-acetylcholinesterase activities of leaf extracts and herbal tea from Dolichandrone serrulata (DC.) Seem were determined. The result showed that extracts and herbal tea samples of D. serrulata leaves had effective in inhibition of amylase (an effective concentration at half maximum (EC₅₀) = 1.21 to 23.80 mg/ml) and acetylcholinesterase activities (EC₅₀ = 2.63 to 49.55 mg/ml). The effect of infusion time on the inhibition of amylase indicated that the best infusion time for preparing herbal tea beverage was 3 min, while the inhibition of acetylcholinesterase was 5 min. The fourier transform infrared spectroscopy (FTIR) and gas chromatograph - mass spectrometer (GC–MS) data indicated the presence of phytochemicals in the extracts and herbal tea samples related to phenolic compounds and flavonoids. The principal component analysis (PCA) result from FTIR data could discriminate herbal tea samples from the ethanol and aqueous extracts better than the PCA biplot of anti-amylase activity and anti-acetylcholinesterase activity.

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细叶多力雄酮叶提取物和凉茶的植物化学成分、抗淀粉酶和抗乙酰胆碱酯酶活性

泰国的老年人口数量持续增长。老年人的主要健康问题是非传染性疾病，即阿尔茨海默病和2型糖尿病。本研究测定了细齿龙叶提取物和凉茶的植物化学成分、抗淀粉酶和抗乙酰胆碱酯酶活性。结果表明，细锯齿叶提取物和凉茶样品对淀粉酶（半数有效浓度EC50为1.21～23.80mg/ml）和乙酰胆碱酯酶活性（EC50为2.63～49.55mg/ml）均有抑制作用对乙酰胆碱酯酶的抑制作用为5min。傅立叶变换红外光谱（FTIR）和气相色谱-质谱（GC–MS）数据表明，提取物和凉茶样品中存在与酚类化合物和黄酮类化合物有关的植物化学物质。FTIR数据的主成分分析（PCA）结果在抗淀粉酶活性和抗乙酰胆碱酯酶活性方面比PCA双标法更好地区分了乙醇和水提取物中的凉茶样品。

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来源期刊

NFS Journal Agricultural and Biological Sciences-Food Science

CiteScore

11.10

自引率

0.00%

发文量

审稿时长

29 days

期刊介绍： The NFS Journal publishes high-quality original research articles and methods papers presenting cutting-edge scientific advances as well as review articles on current topics in all areas of nutrition and food science. The journal particularly invites submission of articles that deal with subjects on the interface of nutrition and food research and thus connect both disciplines. The journal offers a new form of submission Registered Reports (see below). NFS Journal is a forum for research in the following areas: • Understanding the role of dietary factors (macronutrients and micronutrients, phytochemicals, bioactive lipids and peptides etc.) in disease prevention and maintenance of optimum health • Prevention of diet- and age-related pathologies by nutritional approaches • Advances in food technology and food formulation (e.g. novel strategies to reduce salt, sugar, or trans-fat contents etc.) • Nutrition and food genomics, transcriptomics, proteomics, and metabolomics • Identification and characterization of food components • Dietary sources and intake of nutrients and bioactive compounds • Food authentication and quality • Nanotechnology in nutritional and food sciences • (Bio-) Functional properties of foods • Development and validation of novel analytical and research methods • Age- and gender-differences in biological activities and the bioavailability of vitamins, minerals, and phytochemicals and other dietary factors • Food safety and toxicology • Food and nutrition security • Sustainability of food production

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