Effects of fructose from apple and honey on serum uric acid in young Chinese: Randomized crossover trials.

IF 1.3 4区 医学 Q4 NUTRITION & DIETETICS
Yinyin Cheng, Hui Zhang, Yong-fei Zhu, Zhe Xue, Meng Yan, Hui Wang, Shuben Sun, Xiaohong Zhang
{"title":"Effects of fructose from apple and honey on serum uric acid in young Chinese: Randomized crossover trials.","authors":"Yinyin Cheng, Hui Zhang, Yong-fei Zhu, Zhe Xue, Meng Yan, Hui Wang, Shuben Sun, Xiaohong Zhang","doi":"10.6133/apjcn.202203_31(1).0010","DOIUrl":null,"url":null,"abstract":"BACKGROUND AND OBJECTIVES\nOverconsumption of drinks containing fructose increases the risk for hyperuricemia and gout. Comparative analysis evaluating the indicators of serum uric acid (SUA) load caused by natural food-derived fructose and pure fructose in sweeteners is lacking. We aimed to uncover the effect of fructose from apple and honey and pure fructose powder on the SUA concentration of healthy young Chinese individuals.\n\n\nMETHODS AND STUDY DESIGN\nTwo randomized crossover trials were performed. The participants were randomly assigned to consume apple or honey (test food) or pure fructose powder (reference food); one week later, the groups' dietary intervention was switched. Blood samples were collected at 0, 30, 60, and 120 min after meal to measure the SUA and blood glucose concentrations.\n\n\nRESULTS\nAt 30 and 60 min, the SUA concentration in participants consuming apple or honey was lower than in those consuming fructose powder. At 120 min, the SUA concentration of participants consuming apple returned to baseline. The areas under the curve (AUC) within 2 h (2h- AUCs) of SUA exhibited the trend of fructose >honey >apple. The 2h-AUC ratio between test food and reference food was determined using the uric acid index to assess the efficiency of food-derived fructose in increasing the SUA concentration. The uric acid index of honey was higher than that of apple. Men had higher postprandial SUA concentration than women.\n\n\nCONCLUSIONS\nFood-derived fructose caused a lighter load on uric acid metabolism than pure fructose. Uric acid index can be useful for distinguishing fructose-containing foods.","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"31 1 1","pages":"87-96"},"PeriodicalIF":1.3000,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asia Pacific journal of clinical nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.6133/apjcn.202203_31(1).0010","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 1

Abstract

BACKGROUND AND OBJECTIVES Overconsumption of drinks containing fructose increases the risk for hyperuricemia and gout. Comparative analysis evaluating the indicators of serum uric acid (SUA) load caused by natural food-derived fructose and pure fructose in sweeteners is lacking. We aimed to uncover the effect of fructose from apple and honey and pure fructose powder on the SUA concentration of healthy young Chinese individuals. METHODS AND STUDY DESIGN Two randomized crossover trials were performed. The participants were randomly assigned to consume apple or honey (test food) or pure fructose powder (reference food); one week later, the groups' dietary intervention was switched. Blood samples were collected at 0, 30, 60, and 120 min after meal to measure the SUA and blood glucose concentrations. RESULTS At 30 and 60 min, the SUA concentration in participants consuming apple or honey was lower than in those consuming fructose powder. At 120 min, the SUA concentration of participants consuming apple returned to baseline. The areas under the curve (AUC) within 2 h (2h- AUCs) of SUA exhibited the trend of fructose >honey >apple. The 2h-AUC ratio between test food and reference food was determined using the uric acid index to assess the efficiency of food-derived fructose in increasing the SUA concentration. The uric acid index of honey was higher than that of apple. Men had higher postprandial SUA concentration than women. CONCLUSIONS Food-derived fructose caused a lighter load on uric acid metabolism than pure fructose. Uric acid index can be useful for distinguishing fructose-containing foods.
苹果和蜂蜜果糖对中国年轻人血清尿酸的影响:随机交叉试验。
背景与目的过量饮用含有果糖的饮料会增加患高尿酸血症和痛风的风险。缺乏评估甜味剂中天然食品衍生果糖和纯果糖引起的血清尿酸(SUA)负荷指标的比较分析。我们旨在揭示苹果和蜂蜜中的果糖以及纯果糖粉对健康中国年轻人SUA浓度的影响。方法和研究设计进行两项随机交叉试验。参与者被随机分配食用苹果或蜂蜜(测试食品)或纯果糖粉(参考食品);一周后,两组改变了饮食干预。在餐后0、30、60和120分钟采集血样,以测量SUA和血糖浓度。结果在30和60分钟时,食用苹果或蜂蜜的参与者的SUA浓度低于食用果糖粉的参与者。在120分钟时,食用苹果的参与者的SUA浓度恢复到基线。SUA作用2h内的曲线下面积(AUC)呈果糖>蜂蜜>苹果的趋势。使用尿酸指数测定试验食品和参考食品之间的2h AUC比率,以评估食品衍生果糖在增加SUA浓度方面的效率。蜂蜜的尿酸指数高于苹果。男性餐后SUA浓度高于女性。结论:与纯果糖相比,食物来源的果糖对尿酸代谢的影响较小。尿酸指数可用于区分含果糖的食物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
2.50
自引率
7.70%
发文量
58
审稿时长
6-12 weeks
期刊介绍: The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信