Maurice Sopacua , Carla M.L. Gorissen-Brouwers , Bianca T.A. de Greef , Isis B.T. Joosten , Catharina G. Faber , Ingemar S.J. Merkies , Janneke G.J. Hoeijmakers
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Abstract
Objective Stimulated skin wrinkling test (SSW) has been launched as a non-invasive diagnostic procedure. However, no normative age dependent values have been reported that can be applied in clinical practice. The objectives of the study were to (1) collect age-dependent normative values according to the 5-point scale assessment for the SSW, to (2) determine reliability scores for the obtained norm values, and to (3) introduce a new digital method for SSW assessment, the Digit Wrinkle Scan© (DWS©) for detection of wrinkles in a more quantitative manner.
Methods Firstly, 82 healthy participants were included, divided in 5 age groups. The participants underwent SSW using lidocaine and prilocaine topical cream. Secondly, 35 healthy participants were included to test whether the DWS© could be a novel manner to assess the grade of wrinkling quantitatively. We determined the inter-observer reliability of both methods. Also, the intra-observer reliability was calculated for the DWS©.
Results We found a decrease in normative values over age. The inter-observer reliability of assessment by the 5-point scale method was moderate after SSW (Cohen’s k: 0.53). Results of the DWS© indicate that total wrinkle length per mm2 showed moderate to good agreement for the 4th and 5th digits after SSW, and a low agreement for the other digits.
Conclusions Age-dependent normative values were obtained according to the 5-point scale, but its clinical application is doubtful since we found a moderate inter-observer reliability. We introduced the DWS© as a possible new method in order to quantify the grade of wrinkling.
Significance We found unsatisfactory reliability scores, which hampers its usefulness for clinical practice.
手指皱纹扫描量化交感神经功能的适用性
目的:模拟皮肤起皱试验(SSW)作为一种非侵入性的诊断方法已被推出。然而，没有规范的年龄依赖值可用于临床实践的报道。本研究的目的是:(1)根据5分制的SSW评估收集年龄相关的规范值;(2)确定获得的规范值的可靠性评分;(3)引入一种新的数字SSW评估方法，即数字皱纹扫描©(DWS©)，以更定量的方式检测皱纹。方法首先选取健康受试者82例，分为5个年龄组。参与者使用利多卡因和丙胺卡因局部乳膏进行SSW。其次，选取35名健康被试，检验DWS©是否可以作为一种新的定量评估起皱程度的方法。我们确定了两种方法的观察者间信度。同时，计算了DWS©的观察者内信度。结果我们发现，随着年龄的增长，正常值有所下降。SSW后5点量表法评估的观察者间信度为中等(Cohen’s k: 0.53)。DWS©结果表明，SSW后的第4和第5指的总皱纹长度每mm2的一致性中等至良好，而其他手指的一致性较低。结论根据5分制获得了与年龄相关的规范值，但由于我们发现观察者间的信度适中，因此其临床应用值得怀疑。我们引入了DWS©作为一种量化起皱程度的新方法。我们发现信度评分不令人满意，这阻碍了其在临床实践中的应用。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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