Exploratory analysis of the spatial distribution of adult glioma age-adjusted county incidence rates, Nebraska Medicine, 2009-2019.

IF 2.4 Q2 CLINICAL NEUROLOGY

Neuro-oncology practice Pub Date : 2023-08-25 eCollection Date: 2024-02-01 DOI:10.1093/nop/npad050

Kendra L Ratnapradipa, Amulya Yellala, Nicole Shonka

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引用次数: 0

Abstract

Background: Central nervous system (CNS) cancers including gliomas have low incidence but high mortality. The age-adjusted incidence rate for CNS cancers is higher in Nebraska than nationally. This exploratory study was motivated by glioma patient inquiries about possible clustering of cases within the state to see if more in-depth investigation was warranted.

Methods: Using electronic health records from Nebraska Medicine, we identified Nebraska adult (age ≥19) glioma patients diagnosed between January 1, 2009 and November 1, 2019. Patient residential addresses were geocoded, mapped, and combined with annual US Census data to compute age-adjusted incidence rates (AAIR) at the county level. Counties with fewer than five cases were excluded to protect patient identity. ArcGIS software was used for geocoding and mapping.

Results: Of the 285 cases included in the analysis, 53.2% were geocoded with exact match and the remainder were processed manually. Cases occurred in 47 of the 93 counties. After data suppression, 11 counties (228 cases) visually clustered in eastern and central Nebraska with AAIR ranging from 0.85 to 5.66 per 100 000.

Conclusions: Many counties in the state were excluded from analysis of this rare cancer due to the small number of cases leading to unstable rates and the need to suppress data to protect patient privacy. However, this preliminary study suggests that glioma incidence is highest in central and eastern Nebraska. Next steps include analysis of state cancer registry data to ensure more complete case ascertainment.

查看原文本刊更多论文

成人胶质瘤年龄调整县发病率空间分布的探索性分析，内布拉斯加州医学，2009-2019

中枢神经系统(CNS)肿瘤包括神经胶质瘤发病率低但死亡率高。内布拉斯加州经年龄调整的中枢神经系统癌症发病率高于全国。这项探索性研究的动机是神经胶质瘤患者对该州可能聚集性病例的询问，以确定是否有必要进行更深入的调查。使用来自内布拉斯加州医学的电子健康记录，我们确定了2009年1月1日至2019年11月1日期间诊断的内布拉斯加州成人(年龄bb0 - 19岁)胶质瘤患者。对患者的居住地址进行地理编码、绘制地图，并结合美国年度人口普查数据计算县级年龄调整后的发病率(AAIR)。为保护患者身份，病例少于5例的县被排除在外。使用ArcGIS软件进行地理编码和制图。在纳入分析的285例病例中，53.2%的病例进行了精确匹配的地理编码，其余的病例进行了人工处理。93个县中有47个县发生了病例。数据压制后，11个县(228例)视觉聚集在内布拉斯加州东部和中部，AAIR范围为0.85 ~ 5.66 / 10万。该州的许多县都被排除在这种罕见癌症的分析之外，因为病例数量少，导致发病率不稳定，而且需要抑制数据以保护患者隐私。然而，这项初步研究表明，胶质瘤发病率最高的是内布拉斯加州中部和东部。接下来的步骤包括分析州癌症登记数据，以确保更完整的病例确定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuro-oncology practice CLINICAL NEUROLOGY-

CiteScore

5.30

自引率

11.10%

发文量

期刊介绍： Neuro-Oncology Practice focuses on the clinical aspects of the subspecialty for practicing clinicians and healthcare specialists from a variety of disciplines including physicians, nurses, physical/occupational therapists, neuropsychologists, and palliative care specialists, who have focused their careers on clinical patient care and who want to apply the latest treatment advances to their practice. These include: Applying new trial results to improve standards of patient care Translating scientific advances such as tumor molecular profiling and advanced imaging into clinical treatment decision making and personalized brain tumor therapies Raising awareness of basic, translational and clinical research in areas of symptom management, survivorship, neurocognitive function, end of life issues and caregiving