Are obesity and physical fitness associated with cardiovascular disease risk in adolescents with Down syndrome? The longitudinal UP&DOWN study

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-03-30 DOI:10.3109/13668250.2023.2188876

R. Izquierdo-Gómez, I. Esteban‐Cornejo, V. Cabanas‐Sánchez, A. Marcos, S. Gómez-Martínez, J. Castro‐Piñero, Ó. Veiga

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Abstract

ABSTRACT Introduction The aims of this study were to examine cross-sectional, and longitudinal association of different measures of obesity and physical fitness with cardiovascular disease (CVD) risk factors in adolescents with Down syndrome. Methods Longitudinal analysis included 90 adolescents with Down syndrome. Obesity and physical fitness were measured following the ALPHA battery. Blood pressure and blood samplings (glucose, total cholesterol, high-density lipoprotein cholesterol, and serum lipid triglycerides levels (mg/dl) were determinated. Results In cross-sectional analyses, obesity was positively associated with single CVD risk factors and CVD risk factor index (all p < .05). In the prospective analyses, obesity was not associated with single CVD risk factors, but components of physical fitness at baseline impact in some single CVD risk factors (all p < .05). Conclusion Obesity might be more strongly related to current cardiovascular-health, while components of physical fitness might be more related to future cardiovascular-health in adolescents with Down syndrome.

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唐氏综合症青少年的肥胖和身体素质是否与心血管疾病风险相关？纵向上升和下降研究

摘要:本研究的目的是研究唐氏综合征青少年中不同的肥胖和体质测量与心血管疾病(CVD)危险因素的横断面和纵向关联。方法对90例青少年唐氏综合征患者进行纵向分析。肥胖和身体健康是在ALPHA电池之后测量的。测定血压和血样(葡萄糖、总胆固醇、高密度脂蛋白胆固醇和血清脂质甘油三酯水平(mg/dl))。结果在横断面分析中，肥胖与单一CVD危险因素及CVD危险因素指数呈正相关(均p < 0.05)。在前瞻性分析中，肥胖与单一CVD危险因素无关，但基线时身体健康的组成部分对某些单一CVD危险因素有影响(均p < 0.05)。结论肥胖与唐氏综合征青少年当前心血管健康的相关性更强，而身体健康成分与未来心血管健康的相关性更强。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.