Stellungnahme zu Acetaldehyd als Aromastoff: Aspekte der Risikobewertung

IF 1.4 3区 农林科学 Q4 FOOD SCIENCE & TECHNOLOGY
Jan G. Hengstler, Matthias Baum, Alexander T. Cartus, Patrick Diel, Gerhard Eisenbrand, Karl-Heinz Engel, Barbara Engeli, Bernd Epe, Tilman Grune, Sabine Guth, Dirk Haller, Volker Heinz, Michael Hellwig, Thomas Henle, Hans-Ulrich Humpf, Henry Jäger, Hans-Georg Joost, Sabine E. Kulling, Dirk W. Lachenmeier, Alfonso Lampen, Marcel Leist, Angela Mally, Doris Marko, Ute Nöthlings, Elke Röhrdanz, Angelika Roth, Joachim Spranger, Richard Stadler, Pablo Steinberg, Stefan Vieths, Wim Wätjen
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引用次数: 0

Abstract

Opinion on acetaldehyde as a flavouring substance: considerations for risk assessment

Acetaldehyde occurs naturally in many foods and is also used as a flavouring due to its fruity aroma. The International Agency for Research on Cancer (IARC) classified acetaldehyde as possibly carcinogenic to humans and, in combination with oral intake via alcoholic beverages, as carcinogenic to humans. Therefore, the question arises whether the use of acetaldehyde as a flavouring agent is still justifiable. The Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG) reviewed the scientific basis for health risk assessment of the use of acetaldehyde as a flavouring substance and adopted an opinion. Based on the available data, it is at present not possible to conclude if acetaldehyde is genotoxic and mutagenic in vivo after oral exposure. There is also uncertainty regarding the contribution of acetaldehyde as a flavouring substance to the overall exposure to acetaldehyde. Therefore, a science-based assessment on health risk related to the use of acetaldehyde as a flavouring is not possible at present. Considering the genotoxic potential as well as numerous data gaps that need to be closed for a full risk assessment, the SKLM is concerned about the safety of acetaldehyde as a flavouring substance. For reasons of precautionary consumer protection, the SKLM considers that the use of acetaldehyde as a food additive should be re-evaluated.

风险评估
关于乙醛作为调味物质的意见:风险评估的考虑乙醛自然存在于许多食物中,由于其水果香气也被用作调味剂。国际癌症研究机构(IARC)将乙醛列为可能对人类致癌的物质,并且通过酒精饮料口服摄入乙醛,对人类也有致癌作用。因此,问题出现了是否使用乙醛作为调味剂仍然是合理的。德国研究基金会(DFG)的参议院食品安全委员会(SKLM)审查了使用乙醛作为调味物质的健康风险评估的科学依据,并通过了一项意见。根据现有的数据,目前还无法得出乙醛在口服暴露后是否具有遗传毒性和致突变性的结论。关于乙醛作为调味物质对乙醛整体暴露的贡献也存在不确定性。因此,目前不可能对使用乙醛作为调味剂的健康风险进行基于科学的评估。考虑到潜在的遗传毒性以及需要进行全面风险评估的大量数据缺口,SKLM担心乙醛作为调味物质的安全性。出于预防性消费者保护的原因,SKLM认为应重新评估乙醛作为食品添加剂的使用。
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来源期刊
CiteScore
3.70
自引率
4.20%
发文量
46
审稿时长
>12 weeks
期刊介绍: The JCF publishes peer-reviewed original Research Articles and Opinions that are of direct importance to Food and Feed Safety. This includes Food Packaging, Consumer Products as well as Plant Protection Products, Food Microbiology, Veterinary Drugs, Animal Welfare and Genetic Engineering. All peer-reviewed articles that are published should be devoted to improve Consumer Health Protection. Reviews and discussions are welcomed that address legal and/or regulatory decisions with respect to risk assessment and management of Food and Feed Safety issues on a scientific basis. It addresses an international readership of scientists, risk assessors and managers, and other professionals active in the field of Food and Feed Safety and Consumer Health Protection. Manuscripts – preferably written in English but also in German – are published as Research Articles, Reviews, Methods and Short Communications and should cover aspects including, but not limited to: · Factors influencing Food and Feed Safety · Factors influencing Consumer Health Protection · Factors influencing Consumer Behavior · Exposure science related to Risk Assessment and Risk Management · Regulatory aspects related to Food and Feed Safety, Food Packaging, Consumer Products, Plant Protection Products, Food Microbiology, Veterinary Drugs, Animal Welfare and Genetic Engineering · Analytical methods and method validation related to food control and food processing. The JCF also presents important News, as well as Announcements and Reports about administrative surveillance.
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