Age at death and comorbidity of dementia-related disorders among individuals with autism spectrum disorder

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
L. Barnard‐Brak, D. Richman, Zhanxia Yang
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引用次数: 7

Abstract

Purpose Autism spectrum disorder (ASD) is a lifelong disorder that requires intervention and support services for a growing geriatric population. The purpose of this paper is to examine the mean age at death of individuals with ASD and subsequent comorbidity with Alzheimer’s disease, and any form of dementia, as a whole and according to sex. Design/methodology/approach Data consisted of 1,754 individuals who had an ASD listed as one of the causes of deaths from the National Vital Statistics System with data from 1999 to 2015. In the current study, the authors present contradictory results with a mean age at death for individuals with ASD was 68 years by adjusting for changing prevalence rates. Findings Females with ASD had a higher mean age at death than males with ASD; consistent with the trend in the sex differences in the general population. The results of the current study also indicate that individuals with ASD were, in fact, less likely than the general population to have Alzheimer’s disease or a form of dementia. However, males with ASD were significantly more likely to have acquired Alzheimer’s disease or a form of dementia as compared to females with ASD. Originality/value Guan and Li (2017) reported a mean age at death of 36 years old for individuals with ASD, which was subsequently reported in the mass media, most notably CNN. The authors contend that this study provides a more accurate estimate mean age at death.
自闭症谱系障碍患者的死亡年龄和痴呆相关疾病的合并症
目的自闭症谱系障碍(ASD)是一种终身障碍,需要为不断增长的老年人口提供干预和支持服务。本文的目的是根据性别,从整体上研究ASD患者以及随后与阿尔茨海默病和任何形式的痴呆症共病患者的平均死亡年龄。设计/方法/方法数据由1754名ASD患者组成,他们被国家生命统计系统列为死亡原因之一,数据来自1999年至2015年。在目前的研究中,作者提出了相互矛盾的结果,通过调整患病率的变化,ASD患者的平均死亡年龄为68岁。发现患有自闭症谱系障碍的女性平均死亡年龄高于患有自闭症的男性;与一般人群性别差异的趋势一致。目前的研究结果还表明,事实上,ASD患者患阿尔茨海默病或一种痴呆症的可能性低于普通人群。然而,与ASD女性相比,患有ASD的男性患阿尔茨海默病或一种痴呆症的可能性明显更高。原创/价值观Guan和Li(2017)报道了ASD患者的平均死亡年龄为36岁,随后在大众媒体上进行了报道,尤其是CNN。作者认为,这项研究提供了一个更准确的平均死亡年龄估计。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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