Dual and triple encapsulated iron gluconate speed up anemia recovery in an animal model

IF 4.6 Q1 CHEMISTRY, APPLIED
Alberto Baldelli, Yigong Guo, Anubhav Pratap-Singh
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Abstract

Food fortification can be a solution to anemia in developing countries. A previous study determined that the combination of spray drying, hydroxypropyl-methylcellulose as wall material, and maltodextrin as bulk material, encapsulated iron gluconate achieved the highest bioavailability. However, the addition of vitamin B12 to the hydroxypropyl-methylcellulose/maltodextrin capsules increased the iron cell uptake over the previously reported results. The cell viability, the number of live, healthy cells in a sample, of HepG2, human liver cancer cells, increases by about 17% for dual-encapsulated iron gluconate and vitamin b12. The cell uptake in Caco2, human colorectal adenocarcinoma cells, is higher by 25% when using encapsulated iron and vitamin b12 compared to encapsulated iron. The strength of dual-encapsulated iron and vitamin b12 is also confirmed in in-vivo studies. Once fully anemic, young female rats eating food with encapsulated iron gluconate and vitamin b12, show the fastest recovery with respect to rats eating food with encapsulated iron and pure iron. The first needed only five days for their hemoglobulin values to return to normal. The second and the third needed 15 and 21 days, respectively.

Abstract Image

双包封和三包封葡萄糖酸铁在动物模型中加速贫血恢复
食品强化可以解决发展中国家的贫血问题。先前的研究确定,喷雾干燥,羟丙基甲基纤维素作为壁材,麦芽糊精作为散装材料,包封葡萄糖酸铁的生物利用度最高。然而,在羟丙基甲基纤维素/麦芽糊精胶囊中添加维生素B12比先前报道的结果增加了铁细胞的摄取。双包被葡萄糖酸铁和维生素b12的人肝癌细胞HepG2的细胞活力,即样本中活的健康细胞的数量,增加了约17%。当使用铁和维生素b12胶囊时,人类结直肠癌细胞对Caco2的摄取比使用铁胶囊时高25%。铁和维生素b12双胶囊的强度也在体内研究中得到证实。一旦完全贫血,年轻的雌性大鼠吃含有葡萄糖酸铁和维生素b12的食物,比吃含有铁和纯铁的食物恢复得最快。第一组只需要5天他们的血红蛋白值就恢复正常。第二阶段和第三阶段分别需要15天和21天。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.50
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0.00%
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审稿时长
61 days
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