Antidiabetic effect of Borassus flabellifer L. extracts on streptozotocin-induced diabetic rats

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-01-01 DOI:10.4103/bbrj.bbrj_4_23

A. Peter, Nargis Tajudheen, Senthil Ramamoorthy

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Abstract

Background: Around the world, the number of people with diabetes is rising at an alarming rate, and experts have been using ancient drugs that are mostly made from plants as treatments.This study aimed to see if Borassus flabellifer L. palm sprout ethanolic extracts could help treat diabetes in rats made diabetic by streptozotocin (STZ). Methods: STZ (45 mg/kg bw) was injected once into the peritoneum of male albino Wistar rats. This caused them to get diabetes. For 60 days, intragastric intubation was used to give diabetic rats B. flabellifer palm sprout ethanolic extracts (400 mg/kg bw) and glibenclamide (1 mg/kg bw). Results: As a result, the rats lost a lot of weight, their blood sugar and glycosylated hemoglobin levels went up, and their total hemoglobin (Hb) levels went down. Furthermore, glucose-6-phosphatase and fructose-1,6-bis phosphatase were higher in rats made diabetic by STZ, while hexokinase and glycogen levels were lower. When diabetic rats were given ethanolic extracts of B. flabellifer palm sprouts and glibenclamide, their blood glucose and glycosylated Hb levels went down very well, and their Hb levels went up. Changes in how enzymes that break down carbohydrates and liver glycogen work were greatly improved. Conclusion: The results of the ethanolic extracts of B. flabellifer palm sprouts were similar to those of the standard drug glibenclamide. The results of this study back up the traditional use of plant extracts to treat diabetes.

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牛膝草提取物对链脲佐菌素诱导的糖尿病大鼠的降糖作用

背景:在世界范围内，糖尿病患者的数量正以惊人的速度增长，专家们一直在使用主要由植物制成的古老药物作为治疗方法。本研究旨在探讨淫羊藿棕榈芽乙醇提取物对链脲佐菌素(STZ)致糖尿病大鼠的治疗作用。方法:雄性白化Wistar大鼠腹腔注射STZ (45 mg/kg bw) 1次。这导致他们患上糖尿病。连续60天灌胃给予糖尿病大鼠黄叶棕榈芽乙醇提取物(400 mg/kg bw)和格列本脲(1 mg/kg bw)。结果:大鼠体重明显减轻，血糖和糖化血红蛋白水平升高，总血红蛋白(Hb)水平下降。STZ致糖尿病大鼠葡萄糖-6-磷酸酶和果糖-1,6-二磷酸酶水平升高，己糖激酶和糖原水平降低。给糖尿病大鼠以棕榈芽乙醇提取物和格列本脲后，其血糖和糖化Hb水平明显下降，Hb水平明显升高。分解碳水化合物和肝糖原的酶的工作方式发生了很大的变化。结论:棕榈芽乙醇提取物与标准药物格列本脲的测定结果相似。这项研究的结果支持了用植物提取物治疗糖尿病的传统做法。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.