Seroprevalence of hepatitis B viral infection in the okpoko community

IF 1 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biomedical and Biotechnology Research Journal Pub Date : 2022-07-01 DOI:10.4103/bbrj.bbrj_85_22

N. Nwachukwu, C. Okoronkwo, Precious Duru

{"title":"Seroprevalence of hepatitis B viral infection in the okpoko community","authors":"N. Nwachukwu, C. Okoronkwo, Precious Duru","doi":"10.4103/bbrj.bbrj_85_22","DOIUrl":null,"url":null,"abstract":"Background: Hepatitis B virus infection (HBV) is a potentially life-threatening liver infection. Little is known about seroprevalence at the community level. A cross-sectional, community-based study was conducted at Okopko, an urban slum in Ogbaru Local Government Area of Anambra State, Nigeria, using a multistage sampling technique. Stages were the constituency level, ward, and household levels. A total of 867 participants were enrolled. Methods: Testing for the markers of HBV was performed using Diagnostic Kit (USA). The test panel detects hepatitis B surface antigen (HBsAg), hepatitis e antigen (HBeAg), antibody to e antigen (HBeAb), core antibody (HBcAb), and surface antibody (HBsAb) using colloidal gold and membrane chromatographic technology. Results: The seroprevalence of HBsAg was 6.6%. Seroprevalence was higher in males (7.4%) than in females (5.5%) (P > 0.05). The peak seroprevalence occurred in the age group of 40–49 years for both males (13.6%) and females (8.1%) (P < 0.05). Exactly 4.7% were positive for HBeAg and 5.8% for HBsAg + HBeAg + HBcAb. Only 1% was positive for HBsAb. Conclusion: Okpoko community has a high intermediate prevalence rate of HBV infection. The HBV vaccination level is very low in the community.","PeriodicalId":36500,"journal":{"name":"Biomedical and Biotechnology Research Journal","volume":"6 1","pages":"454 - 457"},"PeriodicalIF":1.0000,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical and Biotechnology Research Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/bbrj.bbrj_85_22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Hepatitis B virus infection (HBV) is a potentially life-threatening liver infection. Little is known about seroprevalence at the community level. A cross-sectional, community-based study was conducted at Okopko, an urban slum in Ogbaru Local Government Area of Anambra State, Nigeria, using a multistage sampling technique. Stages were the constituency level, ward, and household levels. A total of 867 participants were enrolled. Methods: Testing for the markers of HBV was performed using Diagnostic Kit (USA). The test panel detects hepatitis B surface antigen (HBsAg), hepatitis e antigen (HBeAg), antibody to e antigen (HBeAb), core antibody (HBcAb), and surface antibody (HBsAb) using colloidal gold and membrane chromatographic technology. Results: The seroprevalence of HBsAg was 6.6%. Seroprevalence was higher in males (7.4%) than in females (5.5%) (P > 0.05). The peak seroprevalence occurred in the age group of 40–49 years for both males (13.6%) and females (8.1%) (P < 0.05). Exactly 4.7% were positive for HBeAg and 5.8% for HBsAg + HBeAg + HBcAb. Only 1% was positive for HBsAb. Conclusion: Okpoko community has a high intermediate prevalence rate of HBV infection. The HBV vaccination level is very low in the community.

查看原文本刊更多论文

okpoko社区乙型肝炎病毒感染的血清流行率

背景：乙型肝炎病毒感染（HBV）是一种潜在的危及生命的肝脏感染。对社区层面的血清流行率知之甚少。在尼日利亚阿南布拉州Ogbaru地方政府区的城市贫民窟Okopko，使用多级采样技术进行了一项基于社区的横断面研究。阶段是选区级别、病房级别和家庭级别。共有867名参与者参加了研究。方法：采用美国诊断试剂盒进行HBV标志物检测。试验组采用胶体金和膜色谱技术检测乙型肝炎表面抗原（HBsAg）、戊型肝炎抗原（HBeAg）、e抗原抗体（HBeAb）、核心抗体（HBcAb）和表面抗体（HBsAb）。结果：HBsAg阳性率为6.6%，男性（7.4%）高于女性（5.5%）（P>0.05），男性（13.6%）和女性（8.1%）在40～49岁年龄组血清阳性率最高（P<0.05），HBeAg阳性率分别为4.7%和5.8%。HBsAb阳性率仅为1%。结论：Okpoko社区具有较高的HBV感染中间流行率。社区的乙肝疫苗接种水平很低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊