Fine-needle aspiration cytology versus open biopsy for the diagnosis of chronic cervical lymphadenopathy

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-01-01 DOI:10.4103/bbrj.bbrj_6_23

Shafia Arshad, Amina Arif, M. Shakeel, Memoona Zahra, Romana Mehwish, Amna Riaz, F. Hadi

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Abstract

Background: For the diagnosis of cervical lymphadenopathy, an open biopsy is recommended. When compared to open biopsy, fine-needle aspiration cytology (FNAC) is considered safe, less invasive, and cost-effective. However, its diagnostic efficacy remains in debates. This study was conducted to know that how accurately FNAC can detect the pathology as compared to an open biopsy. The purpose of this study was to assess the diagnostic efficacy of FNAC versus open biopsy in the diagnosis of cervical lymphadenopathy. Methods: It is a comparative study at Lahore General Hospital, Lahore, for 6 months. The study comprised 100 patients who had been diagnosed with chronic cervical lymphoma. All of the patients underwent FNAC, which was followed by an open biopsy. Calculating the sensitivity, specificity, and diagnostic accuracy of each technique was used to determine the diagnostic efficacy of the both techniques. Results: FNAC had a sensitivity and specificity of 92% overall. Non-Hodgkin's lymphoma, tuberculosis, Hodgkin's lymphoma, metastatic carcinoma, reactive hyperplasia, and chronic nonspecific lymphadenopathy had a diagnostic accuracy of 96.2%, 85.7%, 100%, 87.5%, 100%, and 100%, respectively. Conclusions: In the management of cervical lymphadenopathy, FNAC is a reliable and safe procedure with a high diagnostic efficacy. It should be used as the first line of examination.

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细针抽吸细胞学与开放活检诊断慢性宫颈淋巴结病的比较

背景:对于宫颈淋巴结病的诊断，推荐开放活检。与开放式活检相比，细针穿刺细胞学(FNAC)被认为是安全的，侵入性小，成本效益高。然而，其诊断功效仍存在争议。本研究旨在了解与开放式活检相比，FNAC检测病理的准确性。本研究的目的是评估FNAC与开放活检在诊断宫颈淋巴结病中的诊断效果。方法:在拉合尔市拉合尔总医院进行为期6个月的比较研究。该研究包括100名被诊断为慢性宫颈淋巴瘤的患者。所有患者均行FNAC，随后行开放性活检。计算每种技术的敏感性、特异性和诊断准确性，以确定两种技术的诊断效果。结果:FNAC的敏感性和特异性为92%。非霍奇金淋巴瘤、结核、霍奇金淋巴瘤、转移癌、反应性增生和慢性非特异性淋巴结病的诊断准确率分别为96.2%、85.7%、100%、87.5%、100%和100%。结论:FNAC是一种可靠、安全、诊断效率高的颈部淋巴结病治疗方法。它应该作为第一道检查线。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.