Sensitivity, specificity and positive predictive value of ALEX2 multiplex examination in patients suffering from atopic dermatitis and reaction to egg

IF 1.7 3区农林科学 Q3 CHEMISTRY, APPLIED

Food and Agricultural Immunology Pub Date : 2022-07-05 DOI:10.1080/09540105.2022.2085672

J. Čelakovská, E. Čermáková, R. Vankova, P. Boudková, J. Krejsek, C. Andrys

引用次数: 0

Abstract

ABSTRACT The aim is to evaluate the sensitivity, specificity and positive predictive value of ALEX2 Allergy Explorer test in patients suffering from atopic dermatitis and reactions to egg. We compared the results of specific IgE to allergen reagents (molecular components) with reactions to egg in the open exposure test (OET) (history); the sensitivity, specificity and positive predictictive value were calculated with Fisher's Exact test. Altogether 100 atopic dermatitis patients were examined. The reaction to egg was confirmed in 19 patients (19%). We confirmed significant relation between the results of specific IgE to Gal d 1, Gal d 2, Gal d 3, Gal d 5, Gal d white and Gal d yolk and the results of the OET/history; the sensitivity is in the range 21.05–52.63%. We recommend to evaluate food allergy to egg in patients with severe atopic dermatitis even with negative specific IgE for molecular components.

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ALEX2多重检测对特应性皮炎和鸡蛋反应患者的敏感性、特异性和阳性预测价值

目的评价ALEX2过敏探索者试验在特应性皮炎和鸡蛋反应患者中的敏感性、特异性和阳性预测值。我们比较了开放暴露试验(OET)(病史)中对过敏原试剂(分子成分)的特异性IgE和对鸡蛋的反应;采用Fisher’s Exact检验计算敏感性、特异度和阳性预测值。对100例特应性皮炎患者进行了调查。19例(19%)患者确认对鸡蛋有反应。我们证实了gald1、gald2、gald3、gald1 5、gald蛋白和gald蛋黄的特异性IgE与OET/历史结果之间的显著关系;灵敏度范围为21.05-52.63%。我们建议评估严重特应性皮炎患者对鸡蛋的食物过敏，即使其分子成分特异性IgE为阴性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food and Agricultural Immunology 农林科学-毒理学

CiteScore

5.30

自引率

6.70%

发文量

审稿时长

2 months

期刊介绍： Food and Agricultural Immunology is an international open access journal publishing original immunological research with applications in food, agricultural, environmental and veterinary science. Submissions describing the use of immunological techniques and methods are particularly welcomed. The journal aims to expand our understanding of the interactions at the interface of food and immune systems including studies on: -Development of diagnostic systems – all types of ligand-based assays, e.g. antibody, aptamer -Application of ligand-based assays for the detection or identification of molecules of interest in food science, agricultural research, veterinary investigations and clinical systems relating to food allergy or sensitivity to agricultural chemicals -Effects of food on the immune system -Studies on allergy and allergic reactions -Investigations into food allergies -Development of allergen-free food systems -Development of novel assay formats -Applications of assay systems to the monitoring of food items in relation to safety and labelling -Food quality issues, e.g. speciation, adulteration and contamination -Comparisons between different analytical techniques The journal publishes research and review articles and is essential reading for food scientists, immunologists and all those concerned with the interaction between food and immune systems.