Shellac/caseinate as a composite nanocarrier for improved bioavailability of quercetin

IF 4.6 Q1 CHEMISTRY, APPLIED
Shikha Shiromani , M.M. Patil , Ilaiyaraja Nallamuthu , Rajamanickam R , Dongzagin Singsit , T. Anand
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引用次数: 2

Abstract

In the present study, quercetin (a flavonoid) was encapsulated using biodegradable composite polymers of sodium caseinate and shellac for its improved bioavailability. The quercetin-loaded shellac-caseinate composite nanoparticles (QSNPs) were prepared by anti-solvent precipitation method. Under the optimal combinations of process factors (sodium caseinate 2.5%, shellac 2% and pH 6.8,) the nanocomplexes had the sizes, PDI, zeta potential and encapsulation efficiency of 222 ± 0.19 nm, 0.11, -33.6 mV and 79%, respectively. The optimised nanocolloids were characterised using SEM and AFM microscopes for morphological features. The in vitro release study in simulated gastric and intestinal fluids showed a sustained release of the quercetin from the nanostructures. In rats, the oral administration of single equivalent dosage of quercetin (50 mg/kg b.wt) showed 18.6-fold increase in the relative bioavailability for QSNPs compared to suspension form. These results suggest that the composites of shellac/caseinate matrices can be promising carrier for the oral delivery of hydrophobic phytocompounds with enhanced therapeutic properties in various foods and pharmaceutical applications.

紫胶/酪蛋白酸酯复合纳米载体提高槲皮素的生物利用度
为了提高槲皮素的生物利用度,本研究将槲皮素(一种黄酮类化合物)用酪蛋白酸钠和紫胶的可生物降解复合聚合物进行包封。采用反溶剂沉淀法制备了槲皮素负载的紫胶-酪蛋白酸酯复合纳米颗粒(qsnp)。在最佳工艺条件(酪蛋白酸钠2.5%、紫胶2%、pH 6.8)下,纳米配合物的粒径、PDI、zeta电位和包封效率分别为222±0.19 nm、0.11、-33.6 mV和79%。利用扫描电镜(SEM)和原子力显微镜(AFM)对优化后的纳米胶体进行了形貌表征。体外模拟胃液和肠液释放研究显示槲皮素从纳米结构中持续释放。在大鼠中,单次等效剂量口服槲皮素(50 mg/kg b.wt)的qsnp相对生物利用度比悬吊形式增加18.6倍。这些结果表明,紫胶/酪蛋白酸酯基质复合材料可以作为疏水性植物化合物的口服载体,在各种食品和药物应用中具有增强的治疗性能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.50
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61 days
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