Hepatoprotective and hypoglycemic effect of lactic acid fermented Indian Gooseberry-Amla beverage on chronic alcohol-induced liver damage and diabetes in rats

IF 4.6 Q1 CHEMISTRY, APPLIED
Ritika Modi , ParamPal Sahota , Nitin Dev Singh , Mayank Garg
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Abstract

Background

Plant-based fermented foods rich in lactic acid bacterial metabolites, antioxidants, and phytochemicals, can promote recovery from ethanol-induced liver damage by restoring liver antioxidant levels and suppressing liver inflammation, and improving certain metabolic disorders such as diabetes mellitus.

Methods

In the present study, the protective effects of nutraceutical-enriched lactic acid-fermented Amla beverage on chronic alcohol-induced biochemical modulations and diabetes in Wistar rats were investigated.

Results

The hepatoprotective studies showed that the fermented beverage was able to reverse the damage caused to the liver with ethanol administration in terms of liver index, liver enzymes (AST, ALT), serum enzymes (g-GT), and serum TG, TCH, hepatic TG, LPO levels, antioxidants (GSH, TSOD, CAT, GSH-Px). Along similar lines, in the hypoglycemic studies, the fermented beverage evidently improved body weight, and fasting blood glucose levels, reducing fasting HbAlc levels, improving C-peptide and GLP-1 levels, and alleviating renal dysfunction and lipid metabolism compared with diabetic rats. All these outcomes were supported by histological observations within the liver and pancreas.

Conclusion

The present study suggests that the consumption of fermented Amla beverage may have a protective effect against chronic alcohol-induced toxicity and diabetes. The effects of fermented Amla beverage may be attributed to antioxidant activity, flavonoids, bioactive compounds produced by LAB and their metabolites, which help to counteract free radicals induced by ethanol and in reducing glucagon levels, enhancing glucose utilization, leading to a decrease in blood glucose. The results show that fermented Amla beverage has positive effects in reducing the detrimental effect of alcohol and diabetes.

Abstract Image

乳酸发酵印度鹅膏饮料对大鼠慢性酒精性肝损伤和糖尿病的护肝降血糖作用
富含乳酸菌代谢物、抗氧化剂和植物化学物质的植物性发酵食品可以通过恢复肝脏抗氧化水平、抑制肝脏炎症和改善某些代谢紊乱(如糖尿病)来促进乙醇诱导的肝损伤的恢复。方法研究富营养品乳酸发酵Amla饮料对Wistar大鼠慢性酒精性生化调节和糖尿病的保护作用。结果从肝脏指数、肝酶(AST、ALT)、血清酶(g-GT)、血清TG、TCH、肝脏TG、LPO水平、抗氧化剂(GSH、TSOD、CAT、GSH- px)等方面对乙醇给药的肝脏损伤有明显的逆转作用。同样,在降糖研究中,与糖尿病大鼠相比,发酵饮料明显改善了体重,改善了空腹血糖水平,降低了空腹HbAlc水平,改善了c肽和GLP-1水平,减轻了肾功能和脂质代谢。所有这些结果都得到了肝脏和胰腺组织学观察的支持。结论饮用发酵Amla饮料可能对慢性酒精中毒和糖尿病有保护作用。发酵Amla饮料的作用可能是由于其抗氧化活性、类黄酮及其代谢产物产生的生物活性化合物,有助于抵消乙醇诱导的自由基,降低胰高血糖素水平,提高葡萄糖的利用率,从而降低血糖。结果表明,发酵后的Amla饮料对降低酒精和糖尿病的有害影响具有积极的作用。
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CiteScore
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