Effect of non-digestible oligosaccharides on body weight in overweight and obese adults: A systematic review and meta-analysis of randomised controlled trials
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引用次数: 1
Abstract
Experimental studies suggest potential anti-obesity effects of non-digestible oligosaccharides (NDOs). This study aimed to evaluate the effect of NDO intake on body weight and other anthropometric parameters in overweight or obese adults through a systematic review and meta-analysis of RCTs.
Multiple databases were searched for relevant randomised, controlled trials on NDOs and body weight or associated outcomes. Statistical pooling of data for meta-analysis was performed using the generic inverse-variance method with random-effects models.
Nine trials were included post-screening (n = 455 participants). Increased intake of NDOs resulted in statistically significant reduction in body weight (MD=-0.87 kg [95% CI:-1.55,0.20], p = 0.01) and body fat (-1.56 kg [95% CI:-2.23,-0.89], p<0.00001) relative to control. A risk of bias assessment revealed potential for improvement in reporting/design of most trials.
Increased intake of NDOs significantly reduced body weight and body fat in healthy, overweight and obese adults. This effect was modest and should therefore be interpreted cautiously.
实验研究表明，不可消化寡糖(NDOs)具有潜在的抗肥胖作用。本研究旨在通过对随机对照试验的系统回顾和荟萃分析，评估NDO摄入对超重或肥胖成年人体重和其他人体测量参数的影响。在多个数据库中检索了NDOs与体重或相关结局的相关随机对照试验。采用随机效应模型的通用反方差方法对meta分析数据进行统计池化。筛选后纳入9项试验(n = 455名受试者)。与对照组相比，NDOs摄入量增加导致体重(MD=-0.87 kg [95% CI:-1.55,0.20]， p = 0.01)和体脂(-1.56 kg [95% CI:-2.23，-0.89]， p<0.00001)显著降低。偏倚风险评估揭示了大多数试验报告/设计的改进潜力。在健康、超重和肥胖的成年人中，增加NDOs的摄入量可以显著降低体重和体脂。这种影响是温和的，因此应谨慎解释。
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