Are We Using the Correct Inhaled Medication to Treat Mild Asthma With Low Sputum Eosinophilia?

Q4 Medicine

Clinical Pulmonary Medicine Pub Date : 2019-09-01 DOI:10.1097/CPM.0000000000000320

D. Zappetti

引用次数: 0

Abstract

Synopsis: This crossover trial evaluated the efficacy of inhaled corticosteroids and long-acting muscarinic antagonists compared with placebo in asthmatic patients in relation to sputum eosinophil counts. No statistical significance was found between the Mometasone versus placebo or the Tiotropium versus placebo groups, and the responses to the active drugs were not greater than the responses to the placebo medications in those with a low sputum eosinophil count. Source: Lazarus SC, Krishnan JA, King TS, et al. Mometasone or Tiotropium in mild asthma with a low sputum eosinophil level. NEJM. 2019;380:2009–2019.

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我们是否使用正确的吸入药物治疗轻度哮喘伴低痰嗜酸性粒细胞增多症？

摘要:本交叉试验评估了吸入皮质类固醇和长效毒蕈碱拮抗剂与安慰剂对哮喘患者痰嗜酸性粒细胞计数的影响。莫米松组与安慰剂组或噻托品组与安慰剂组之间没有统计学意义，并且在痰嗜酸性粒细胞计数低的患者中，对活性药物的反应并不大于对安慰剂药物的反应。来源:Lazarus SC, Krishnan JA, King TS等。莫米松或噻托溴铵治疗痰嗜酸性粒细胞水平低的轻度哮喘。NEJM。2019; 380:2009 - 2019。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Pulmonary Medicine Medicine-Critical Care and Intensive Care Medicine

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期刊介绍： Clinical Pulmonary Medicine provides a forum for the discussion of important new knowledge in the field of pulmonary medicine that is of interest and relevance to the practitioner. This goal is achieved through mini-reviews on focused sub-specialty topics in areas covered within the journal. These areas include: Obstructive Airways Disease; Respiratory Infections; Interstitial, Inflammatory, and Occupational Diseases; Clinical Practice Management; Critical Care/Respiratory Care; Colleagues in Respiratory Medicine; and Topics in Respiratory Medicine.