Electroencephalographic-Based Functional Connectivity Networks of Visual Hallucinations and Visuospatial Dysfunctions in Parkinson’s Disease

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

European Neurology Pub Date : 2022-04-28 DOI:10.1159/000524365

K. Kinugawa, T. Mano, T. Takatani, A. Kido, K. Sugie

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引用次数: 0

Abstract

Visual dysfunction is an important nonmotor symptom of Parkinson’s disease (PD). Visual hallucinations (VHs) and visuospatial dysfunctions (VSDs) are common visual dysfunctions in PD; however, the underlying mechanisms remain unclear. Our study aimed to evaluate neuronal synchronization between patients with PD with and without VH or VSD using electroencephalographic (EEG) coherence analysis. Twenty-four patients with sporadic PD were evaluated for the presence of VH and VSD, and were divided into VH-negative and VH-positive groups, and these groups were further subdivided by VSD status. Coherence analysis was performed on EEG data. Whole-brain and regional coherences were calculated and compared between the groups. There was a significant difference in frontal-frontal coherence between the VH+ VSD− and VH+ VSD+ groups (p = 0.026). Our findings suggest that reduced EEG coherence in frontal regions might be involved in VSD in patients with PD. Reduced neuronal synchronization between the frontal lobes may contribute to the disruption of visual processing in PD.

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帕金森病视觉幻觉和视空间功能障碍的脑电图功能连接网络

视觉功能障碍是帕金森病的一个重要的非运动症状。视幻觉（VHs）和视空间功能障碍（VSD）是PD常见的视觉功能障碍；然而，其根本机制仍不清楚。我们的研究旨在使用脑电图（EEG）连贯性分析来评估伴有和不伴有VH或VSD的PD患者之间的神经元同步性。对24例散发性帕金森病患者进行了VH和VSD的评估，并将其分为VH阴性组和VH阳性组，这些组根据VSD状态进一步细分。对脑电数据进行相干分析。计算并比较各组之间的全脑和区域连贯性。VH+VSD−和VH+VSD+组的额叶连贯性存在显著差异（p=0.026）。我们的研究结果表明，PD患者的VSD可能与额叶脑电连贯性降低有关。额叶之间神经元同步性降低可能导致PD视觉处理中断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Neurology 医学-临床神经学

CiteScore

4.40

自引率

4.20%

发文量

审稿时长

4-8 weeks

期刊介绍： ''European Neurology'' publishes original papers, reviews and letters to the editor. Papers presented in this journal cover clinical aspects of diseases of the nervous system and muscles, as well as their neuropathological, biochemical, and electrophysiological basis. New diagnostic probes, pharmacological and surgical treatments are evaluated from clinical evidence and basic investigative studies. The journal also features original works and reviews on the history of neurology.