Blood Oxygen Sensor Using a Boron-Doped Diamond Electrode

IF 6.7 1区 化学 Q1 CHEMISTRY, ANALYTICAL
Yunita Triana, Genki Ogata, Mai Tomisaki,  Irkham, Yasuaki Einaga*
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引用次数: 3

Abstract

The electrochemical behavior of oxygen (O2) in blood was studied using boron-doped diamond (BDD) electrodes. Cyclic voltammogram of O2 in a 0.1 M phosphate buffer solution solution containing 1 × 10–6 M of bovine hemoglobin exhibits a reduction peak at ?1.4 V (vs Ag/AgCl). Moreover, the scan rate dependence was investigated to study the reduction reaction mechanism, which was attributable to the reduction of O2 to H2O2 via two electrons. A linear calibration curve was observed in the concentration range of 86.88–314.63 mg L–1 (R2 = 0.99) with a detection limit of 1.0 mg L–1 (S/B = 3). The analytical performance was better than those with glassy carbon or platinum electrodes as the working electrode. In addition, an application to bovine blood was performed. The O2 concentration in the blood measured on the BDD electrodes was compared to that measured using an OxyLite Pro fiber-optic oxygen sensor device. Both methods gave similar values of the O2 concentration in the range of ~40 to 150 mmHg. This result confirms that BDD electrodes could potentially be used to detect the O2 concentration in blood.

Abstract Image

使用掺硼金刚石电极的血氧传感器
采用掺硼金刚石(BDD)电极研究了血液中氧的电化学行为。氧在含有1 × 10-6 M牛血红蛋白的0.1 M磷酸盐缓冲溶液中的循环伏安图显示,还原峰在- 1.4 V (vs Ag/AgCl)。此外,研究了扫描速率的依赖性,研究了还原反应机理,这是由于O2通过两个电子还原为H2O2。在浓度86.88 ~ 314.63 mg L-1范围内呈线性曲线(R2 = 0.99),检出限为1.0 mg L-1 (S/B = 3),分析性能优于以玻碳电极或铂电极作为工作电极。此外,还对牛血液进行了应用。在BDD电极上测量的血液中的氧浓度与使用OxyLite Pro光纤氧传感器装置测量的结果进行了比较。两种方法在~40 ~ 150mmhg范围内的O2浓度值相似。这一结果证实,BDD电极有可能用于检测血液中的氧浓度。
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来源期刊
Analytical Chemistry
Analytical Chemistry 化学-分析化学
CiteScore
12.10
自引率
12.20%
发文量
1949
审稿时长
1.4 months
期刊介绍: Analytical Chemistry, a peer-reviewed research journal, focuses on disseminating new and original knowledge across all branches of analytical chemistry. Fundamental articles may explore general principles of chemical measurement science and need not directly address existing or potential analytical methodology. They can be entirely theoretical or report experimental results. Contributions may cover various phases of analytical operations, including sampling, bioanalysis, electrochemistry, mass spectrometry, microscale and nanoscale systems, environmental analysis, separations, spectroscopy, chemical reactions and selectivity, instrumentation, imaging, surface analysis, and data processing. Papers discussing known analytical methods should present a significant, original application of the method, a notable improvement, or results on an important analyte.
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