Anticancer activity of tin oxide and cerium-doped tin oxide nanoparticles synthesized from Ipomoea carnea flower extract

IF 1 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biomedical and Biotechnology Research Journal Pub Date : 2022-07-01 DOI:10.4103/bbrj.bbrj_100_22

M. Prasanth, Gurusamy Muruganandam, K. Ravichandran, Gnanasekar Dayana Jeyaleela, K. Shanthaseelan, Baskaran Priyadharshini

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引用次数: 2

Abstract

Background: The aim of the study is to investigate the anticancer potential of tin oxide (SnO2) and different concentrations (2%, 4%, 6%, and 8%) of cerium-doped tin oxide nanoparticles (Ce-SnO2 NPs) using Ipomoea carnea flower extract. The synthesized SnO2 and different concentrations (2%, 4%, 6%, and 8%) of Ce-SnO2 NPs was tested using a colorimetric-based 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay against MCF-7 human breast cancer cell line cells. Methods: Collection and preparation of plant extract is preliminarily carried out followed by the synthesis of Undoped and Cerium doped Tin oxide nanoparticles is achieved by standard protocol along with that its anticancer activity also studied in this research. Results: The anticancer activity increased in direct proportion to the cerium-dopant concentration. Experimental results demonstrated that 8% Ce-SnO2 NPs exhibited a potential anticancer effect compared with SnO2 and other concentrations of Ce-SnO2 NPs. Conclusion: According to the current findings, large-scale manufacturing of Ce-SnO2 NPs might be recommended to have effective anticancer agents against breast cancer cell lines.

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肉苁蓉提取物合成氧化锡和铈掺杂氧化锡纳米粒子的抗癌活性

背景:研究不同浓度(2%、4%、6%和8%)掺铈氧化锡纳米粒子(Ce-SnO2 NPs)对易普罗亚花提取物中氧化锡(SnO2)的抗癌作用。采用比色法检测合成的SnO2和不同浓度(2%、4%、6%和8%)的Ce-SnO2 NPs对MCF-7人乳腺癌细胞系细胞的杀伤作用。方法:对植物提取物进行初步收集和制备，按照标准方案合成未掺杂和掺铈氧化锡纳米颗粒，并对其抗癌活性进行研究。结果:其抗癌活性与铈掺杂浓度成正比。实验结果表明，与SnO2和其他浓度的Ce-SnO2 NPs相比，8% Ce-SnO2 NPs具有潜在的抗癌作用。结论:根据目前的研究结果，大规模生产Ce-SnO2 NPs可能是针对乳腺癌细胞系的有效抗癌药物。

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