Tissue-derived extracellular vesicles in cancer progression: mechanisms, roles, and potential applications.

IF 7.7 2区医学 Q1 ONCOLOGY

Cancer and Metastasis Reviews Pub Date : 2024-06-01 Epub Date: 2023-10-18 DOI:10.1007/s10555-023-10147-6

Ziyang Ye, Wenjie Chen, Genpeng Li, Jing Huang, Jianyong Lei

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引用次数: 0

Abstract

Extracellular vesicles (EVs) are small lipid bilayer-enclosed vesicles that mediate vital cellular communication by transferring cargo between cells. Among these, tissue-derived extracellular vesicles (Ti-EVs) stand out due to their origin from the tissue microenvironment, providing a more accurate reflection of changes in this setting. This unique advantage makes Ti-EVs valuable in investigating the intricate relationship between extracellular vesicles and cancer progression. Despite considerable research efforts exploring the association between Ti-EVs and cancers, a comprehensive clustering or grouping of these studies remains lacking. In this review, we aim to fill this gap by presenting a comprehensive synthesis of the mechanisms underlying Ti-EV generation, release, and transport within cancer tissues. Moreover, we delve into the pivotal roles that Ti-EVs play in cancer progression, shedding light on their potential as diagnostic and therapeutic tools. The review culminates in the construction of a comprehensive functional spectrum of Ti-EVs, providing a valuable reference for future research endeavors. By summarizing the current state of knowledge on Ti-EVs and their significance in tumor biology, this work contributes to a deeper understanding of cancer microenvironment dynamics and opens up avenues for harnessing Ti-EVs in diagnostic and therapeutic applications.

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癌症进展中的组织衍生细胞外小泡：机制、作用和潜在应用。

细胞外小泡（EVs）是一种小型脂质双层封闭的小泡，通过在细胞之间转移货物来介导重要的细胞通讯。其中，组织衍生的细胞外小泡（Ti-EVs）因其来源于组织微环境而脱颖而出，从而更准确地反映了这种情况下的变化。这种独特的优势使Ti-EV在研究细胞外小泡与癌症进展之间的复杂关系方面具有价值。尽管在探索Ti EV与癌症之间的联系方面进行了大量的研究，但这些研究仍然缺乏全面的聚类或分组。在这篇综述中，我们旨在通过对癌症组织中Ti-EV产生、释放和转运的潜在机制进行全面综合来填补这一空白。此外，我们深入研究了Ti-EV在癌症进展中的关键作用，揭示了它们作为诊断和治疗工具的潜力。该综述的高潮是构建了一个全面的Ti EV功能谱，为未来的研究工作提供了宝贵的参考。通过总结Ti-EV的知识现状及其在肿瘤生物学中的意义，这项工作有助于加深对癌症微环境动力学的理解，并为在诊断和治疗应用中利用Ti-EV开辟途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer and Metastasis Reviews 医学-肿瘤学

CiteScore

17.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Contemporary biomedical research is on the threshold of an era in which physiological and pathological processes can be analyzed in increasingly precise and mechanistic terms.The transformation of biology from a largely descriptive, phenomenological discipline to one in which the regulatory principles can be understood and manipulated with predictability brings a new dimension to the study of cancer and the search for effective therapeutic modalities for this disease. Cancer and Metastasis Reviews provides a forum for critical review and discussion of these challenging developments. A major function of the journal is to review some of the more important and interesting recent developments in the biology and treatment of malignant disease, as well as to highlight new and promising directions, be they technological or conceptual. Contributors are encouraged to review their personal work and be speculative.